Sequence Detail

ID/Version

Q9WUE4 (UniProt | EBI)

Last sequence update: 1999-11-01
Last annotation update: 2025-06-18

Sequence description from provider

RecName: Full=GATOR1 complex protein NPRL2 {ECO:0000305};AltName: Full=Gene 21 protein {ECO:0000312|EMBL:AAD33474.1}; Short=G21 protein {ECO:0000312|EMBL:AAD33474.1};AltName: Full=Nitrogen permease regulator 2-like protein {ECO:0000312|MGI:MGI:191

Provider

SWISS-PROT

Sequence

Polypeptide 380 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Nprl2	NPR2 like, GATOR1 complex subunit	34	97	3	11

Sequence references in MGI

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:224837 Dutchak PA, et al., Regulation of Hematopoiesis and Methionine Homeostasis by mTORC1 Inhibitor NPRL2. Cell Rep. 2015 Jul 21;12(3):371-9
J:271536 Dutchak PA, et al., Loss of a Negative Regulator of mTORC1 Induces Aerobic Glycolysis and Altered Fiber Composition in Skeletal Muscle. Cell Rep. 2018 May 15;23(7):1907-1914
J:345007 Jiang C, et al., PRMT1 orchestrates with SAMTOR to govern mTORC1 methionine sensing via Arg-methylation of NPRL2. Cell Metab. 2023 Dec 5;35(12):2183-2199.e7