Sequence Detail

ID/Version

Q9WUA6 (UniProt | EBI)

Last sequence update: 1999-11-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=RAC-gamma serine/threonine-protein kinase; EC=2.7.11.1;AltName: Full=Protein kinase Akt-3;AltName: Full=Protein kinase B gamma; Short=PKB gamma;AltName: Full=RAC-PK-gamma;

Provider

SWISS-PROT

Sequence

Polypeptide 479 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Akt3	thymoma viral proto-oncogene 3	66	113	4	18

Sequence references in MGI

J:54026 Brodbeck D, et al., A human protein kinase Bgamma with regulatory phosphorylation sites in the activation loop and in the C-terminal hydrophobic domain. J Biol Chem. 1999 Apr 2;274(14):9133-6
J:70720 Brodbeck D, et al., Two Splice Variants of Protein Kinase Bgamma Have Different Regulatory Capacity Depending on the Presence or Absence of the Regulatory Phosphorylation Site Serine 472 in the Carboxyl-terminal Hydrophobic Domain. J Biol Chem. 2001 Aug 3;276(31):29550-8
J:96823 Easton RM, et al., Role for Akt3/protein kinase Bgamma in attainment of normal brain size. Mol Cell Biol. 2005 Mar;25(5):1869-78
J:138636 Wright GL, et al., VEGF stimulation of mitochondrial biogenesis: requirement of AKT3 kinase. FASEB J. 2008 Sep;22(9):3264-75
J:169028 Tokuda S, et al., A novel Akt3 mutation associated with enhanced kinase activity and seizure susceptibility in mice. Hum Mol Genet. 2011 Mar 1;20(5):988-99
J:213891 Nawa M, et al., KCTD20, a relative of BTBD10, is a positive regulator of Akt. BMC Biochem. 2013;14:27
J:213903 Nawa M, et al., A novel Akt/PKB-interacting protein promotes cell adhesion and inhibits familial amyotrophic lateral sclerosis-linked mutant SOD1-induced neuronal death via inhibition of PP2A-mediated dephosphorylation of Akt/PKB. Cell Signal. 2008 Mar;20(3):493-505
J:260006 Mounir Z, et al., Akt determines cell fate through inhibition of the PERK-eIF2alpha phosphorylation pathway. Sci Signal. 2011 Sep 27;4(192):ra62
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89