Sequence Detail

ID/Version

Q9WU42 E9Q9V0 Q9WUC1 Q9WU43 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Nuclear receptor corepressor 2; Short=N-CoR2;AltName: Full=Silencing mediator of retinoic acid and thyroid hormone receptor {ECO:0000303|PubMed:10077563}; Short=SMRT {ECO:0000303|PubMed:10077563}; Short=SMRTe {ECO:000

Provider

SWISS-PROT

Sequence

Polypeptide 2472 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Ncor2	nuclear receptor co-repressor 2	83	112	3	139

Sequence references in MGI

J:46724 Zamir I, et al., Cloning and characterization of a corepressor and potential component of the nuclear hormone receptor repression complex. Proc Natl Acad Sci U S A. 1997 Dec 23;94(26):14400-5
J:53498 Ordentlich P, et al., Unique forms of human and mouse nuclear receptor corepressor SMRT. Proc Natl Acad Sci U S A. 1999 Mar 16;96(6):2639-44
J:54023 Park EJ, et al., SMRTe, a silencing mediator for retinoid and thyroid hormone receptors-extended isoform that is more related to the nuclear receptor corepressor. Proc Natl Acad Sci U S A. 1999 Mar 30;96(7):3519-24
J:64684 Kao HY, et al., Isolation of a novel histone deacetylase reveals that class I and class II deacetylases promote SMRT-mediated repression. Genes Dev. 2000 Jan 1;14(1):55-66
J:143718 Trost M, et al., The phagosomal proteome in interferon-gamma-activated macrophages. Immunity. 2009 Jan;30(1):143-54
J:144189 Jacobs FM, et al., Pitx3 potentiates Nurr1 in dopamine neuron terminal differentiation through release of SMRT-mediated repression. Development. 2009 Feb;136(4):531-40
J:194821 Huang C, et al., Lineage-specific functions of Bcl-6 in immunity and inflammation are mediated by distinct biochemical mechanisms. Nat Immunol. 2013 Apr;14(4):380-8
J:203468 Park J, et al., SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. Mol Cell. 2013 Jun 27;50(6):919-30
J:203745 Lyst MJ, et al., Rett syndrome mutations abolish the interaction of MeCP2 with the NCoR/SMRT co-repressor. Nat Neurosci. 2013 Jul;16(7):898-902
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:306378 Guo A, et al., Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. Mol Cell Proteomics. 2014 Jan;13(1):372-87
J:322384 Zheng S, et al., The uncharacterized SANT and BTB domain-containing protein SANBR inhibits class switch recombination. J Biol Chem. 2021 Apr 5;:100625