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Sequence Detail
Q9WTU3 Q62449 Q60828 Q3TYI3 Q60858 (UniProt | EBI) Last sequence update: 1999-11-01
Last annotation update: 2018-02-28
from provider
RecName: Full=Sodium channel protein type 8 subunit alpha;AltName: Full=Sodium channel protein type VIII subunit alpha;AltName: Full=Voltage-gated sodium channel subunit alpha Nav1.6;
Polypeptide 1978 aa
For this sequence
Organism mouse
See UniProt | EBI for source
Annotated genes and markers Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.
Type Symbol Name GO Terms Expression
Orthologs Phenotypic
Gene Scn8a sodium channel, voltage-gated, type VIII, alpha 40 9 10 38
Sequence references in MGI J:27739 Burgess DL, et al., Mutation of a new sodium channel gene, Scn8a, in the mouse mutant 'motor endplate disease'. Nat Genet. 1995 Aug;10(4):461-5
J:34154 Kohrman DC, et al., Mutation detection in the med and medJ alleles of the sodium channel Scn8a. Unusual splicing due to a minor class AT-AC intron. J Biol Chem. 1996 Jul 19;271(29):17576-81
J:35567 Kohrman DC, et al., A missense mutation in the sodium channel Scn8a is responsible for cerebellar ataxia in the mouse mutant jolting. J Neurosci. 1996 Oct 1;16(19):5993-9
J:43018 Plummer NW, et al., Alternative splicing of the sodium channel SCN8A predicts a truncated two-domain protein in fetal brain and non-neuronal cells. J Biol Chem. 1997 Sep 19;272(38):24008-15
J:51398 Plummer NW, et al., Exon organization, coding sequence, physical mapping, and polymorphic intragenic markers for the human neuronal sodium channel gene SCN8A. Genomics. 1998 Dec 1;54(2):287-96
J:71615 De Repentigny Y, et al., Pathological and genetic analysis of the degenerating muscle (dmu) mouse: a new allele of Scn8a. Hum Mol Genet. 2001 Aug 15;10(17):1819-27
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:148621 Carrithers MD, et al., Regulation of podosome formation in macrophages by a splice variant of the sodium channel SCN8A. J Biol Chem. 2009 Mar 20;284(12):8114-26

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last database update
MGI 6.11
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