Sequence Detail

ID/Version

Q9WTU3 Q60828 Q60858 Q62449 Q3TYI3 (UniProt | EBI)

Last sequence update: 1999-11-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Sodium channel protein type 8 subunit alpha;AltName: Full=Sodium channel protein type VIII subunit alpha;AltName: Full=Voltage-gated sodium channel subunit alpha Nav1.6 {ECO:0000303|PubMed:19136557};

Provider

SWISS-PROT

Sequence

Polypeptide 1978 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Scn8a	sodium channel, voltage-gated, type VIII, alpha	72	107	4	46

Sequence references in MGI

J:27739 Burgess DL, et al., Mutation of a new sodium channel gene, Scn8a, in the mouse mutant 'motor endplate disease'. Nat Genet. 1995 Aug;10(4):461-5
J:34154 Kohrman DC, et al., Mutation detection in the med and medJ alleles of the sodium channel Scn8a. Unusual splicing due to a minor class AT-AC intron. J Biol Chem. 1996 Jul 19;271(29):17576-81
J:35567 Kohrman DC, et al., A missense mutation in the sodium channel Scn8a is responsible for cerebellar ataxia in the mouse mutant jolting. J Neurosci. 1996 Oct 1;16(19):5993-9
J:43018 Plummer NW, et al., Alternative splicing of the sodium channel SCN8A predicts a truncated two-domain protein in fetal brain and non-neuronal cells. J Biol Chem. 1997 Sep 19;272(38):24008-15
J:51398 Plummer NW, et al., Exon organization, coding sequence, physical mapping, and polymorphic intragenic markers for the human neuronal sodium channel gene SCN8A. Genomics. 1998 Dec 1;54(2):287-96
J:71615 De Repentigny Y, et al., Pathological and genetic analysis of the degenerating muscle (dmu) mouse: a new allele of Scn8a. Hum Mol Genet. 2001 Aug 15;10(17):1819-27
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:148621 Carrithers MD, et al., Regulation of podosome formation in macrophages by a splice variant of the sodium channel SCN8A. J Biol Chem. 2009 Mar 20;284(12):8114-26
J:252750 Liu Y, et al., CDYL suppresses epileptogenesis in mice through repression of axonal Nav1.6 sodium channel expression. Nat Commun. 2017 Aug 25;8(1):355
J:333673 Fotia AB, et al., Regulation of neuronal voltage-gated sodium channels by the ubiquitin-protein ligases Nedd4 and Nedd4-2. J Biol Chem. 2004 Jul 9;279(28):28930-5