Sequence Detail

ID/Version

Q9WTN3 Q3U458 Q99JK7 Q8C733 Q5SRX5 Q3UDJ3 (UniProt | EBI)

Last sequence update: 2007-07-24
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Sterol regulatory element-binding protein 1 {ECO:0000303|PubMed:10052151, ECO:0000303|PubMed:9062340}; Short=SREBP-1 {ECO:0000303|PubMed:10052151, ECO:0000303|PubMed:9062340};AltName: Full=Sterol regulatory element-binding transcript

Provider

SWISS-PROT

Sequence

Polypeptide 1134 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Srebf1	sterol regulatory element binding transcription factor 1	143	110	3	28

Sequence references in MGI

J:35770 Shimano H, et al., Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a [see comments]. J Clin Invest. 1996 Oct 1;98(7):1575-84
J:43570 Shimano H, et al., Elevated levels of SREBP-2 and cholesterol synthesis in livers of mice homozygous for a targeted disruption of the SREBP-1 gene [see comments]. J Clin Invest. 1997 Oct 15;100(8):2115-24
J:50770 Shimomura I, et al., Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP-1c in adipose tissue: model for congenital generalized lipodystrophy. Genes Dev. 1998 Oct 15;12(20):3182-94
J:53660 Inoue J, et al., A novel splicing isoform of mouse sterol regulatory element-binding protein-1 (SREBP-1). Biosci Biotechnol Biochem. 1999 Jan;63(1):243-5
J:75320 Liang G, et al., Diminished Hepatic Response to Fasting/Refeeding and Liver X Receptor Agonists in Mice with Selective Deficiency of Sterol Regulatory Element-binding Protein-1c. J Biol Chem. 2002 Mar 15;277(11):9520-8
J:85534 Horton JD, et al., Overexpression of sterol regulatory element-binding protein-1a in mouse adipose tissue produces adipocyte hypertrophy, increased fatty acid secretion, and fatty liver. J Biol Chem. 2003 Sep 19;278(38):36652-60
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:101203 Engelking LJ, et al., Schoenheimer effect explained - feedback regulation of cholesterol synthesis in mice mediated by Insig proteins. J Clin Invest. 2005 Sep;115(9):2489-98
J:108164 Shimano H, et al., Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells. J Clin Invest. 1997 Mar 1;99(5):846-54
J:120098 Pedersen TA, et al., Distinct C/EBPalpha motifs regulate lipogenic and gluconeogenic gene expression in vivo. EMBO J. 2007 Feb 21;26(4):1081-93
J:172248 Li Y, et al., AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice. Cell Metab. 2011 Apr 6;13(4):376-88
J:175815 Im SS, et al., Linking lipid metabolism to the innate immune response in macrophages through sterol regulatory element binding protein-1a. Cell Metab. 2011 May 4;13(5):540-9
J:177249 Yoon YS, et al., Salt-inducible kinase regulates hepatic lipogenesis by controlling SREBP-1c phosphorylation. J Biol Chem. 2009 Apr 17;284(16):10446-52
J:211246 Cho Y, et al., The basic helix-loop-helix proteins differentiated embryo chondrocyte (DEC) 1 and DEC2 function as corepressors of retinoid X receptors. Mol Pharmacol. 2009 Dec;76(6):1360-9
J:224972 Xu D, et al., PAQR3 modulates cholesterol homeostasis by anchoring Scap/SREBP complex to the Golgi apparatus. Nat Commun. 2015;6:8100
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:338255 Cheng L, et al., Hepatic mitochondrial NAD + transporter SLC25A47 activates AMPKalpha mediating lipid metabolism and tumorigenesis. Hepatology. 2023 Feb 22;