Sequence Detail

ID/Version

Q9WTL8 Q9WTL9 O88295 Q9R0U2 Q921S4 (UniProt | EBI)

Last sequence update: 2003-08-15
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=Basic helix-loop-helix ARNT-like protein 1;AltName: Full=Arnt3;AltName: Full=Aryl hydrocarbon receptor nuclear translocator-like protein 1;AltName: Full=Brain and muscle ARNT-like 1;

Provider

SWISS-PROT

Sequence

Polypeptide 632 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Bmal1	basic helix-loop-helix ARNT like 1	124	138	4	93

Sequence references in MGI

J:48067 Gekakis N, et al., Role of the CLOCK protein in the mammalian circadian mechanism [see comments]. Science. 1998 Jun 5;280(5369):1564-9
J:49044 Takahata S, et al., Transcriptionally active heterodimer formation of an Arnt-like PAS protein, Arnt3, with HIF-1a, HLF, and clock. Biochem Biophys Res Commun. 1998 Jul 30;248(3):789-94
J:56805 Yu W, et al., Characterization of three splice variants and genomic organization of the mouse BMAL1 gene. Biochem Biophys Res Commun. 1999 Jul 14;260(3):760-7
J:73655 Lee C, et al., Posttranslational mechanisms regulate the mammalian circadian clock. Cell. 2001 Dec 28;107(7):855-67
J:79730 Honma S, et al., Dec1 and Dec2 are regulators of the mammalian molecular clock. Nature. 2002 Oct 24;419(6909):841-4
J:84699 Kondratov RV, et al., BMAL1-dependent circadian oscillation of nuclear CLOCK: posttranslational events induced by dimerization of transcriptional activators of the mammalian clock system. Genes Dev. 2003 Aug 1;17(15):1921-32
J:87263 Kawamoto T, et al., A novel autofeedback loop of Dec1 transcription involved in circadian rhythm regulation. Biochem Biophys Res Commun. 2004 Jan 2;313(1):117-24
J:100231 Cardone L, et al., Circadian clock control by SUMOylation of BMAL1. Science. 2005 Aug 26;309(5739):1390-4
J:112955 Kwon I, et al., BMAL1 shuttling controls transactivation and degradation of the CLOCK/BMAL1 heterodimer. Mol Cell Biol. 2006 Oct;26(19):7318-30
J:116444 Etchegaray JP, et al., The polycomb group protein EZH2 is required for mammalian circadian clock function. J Biol Chem. 2006 Jul 28;281(30):21209-15
J:130591 Hirayama J, et al., CLOCK-mediated acetylation of BMAL1 controls circadian function. Nature. 2007 Dec 13;450(7172):1086-90
J:135812 Bertolucci C, et al., Evidence for an overlapping role of CLOCK and NPAS2 transcription factors in liver circadian oscillators. Mol Cell Biol. 2008 May;28(9):3070-5
J:139295 Nakahata Y, et al., The NAD+-dependent deacetylase SIRT1 modulates CLOCK-mediated chromatin remodeling and circadian control. Cell. 2008 Jul 25;134(2):329-40
J:139296 Asher G, et al., SIRT1 regulates circadian clock gene expression through PER2 deacetylation. Cell. 2008 Jul 25;134(2):317-28
J:140360 Lee J, et al., Dual modification of BMAL1 by SUMO2/3 and ubiquitin promotes circadian activation of the CLOCK/BMAL1 complex. Mol Cell Biol. 2008 Oct;28(19):6056-65
J:143808 Langmesser S, et al., Interaction of circadian clock proteins PER2 and CRY with BMAL1 and CLOCK. BMC Mol Biol. 2008;9:41
J:147991 Ramsey KM, et al., Circadian clock feedback cycle through NAMPT-mediated NAD+ biosynthesis. Science. 2009 May 1;324(5927):651-4
J:147996 Nakahata Y, et al., Circadian control of the NAD+ salvage pathway by CLOCK-SIRT1. Science. 2009 May 1;324(5927):654-7
J:148217 Nader N, et al., Circadian rhythm transcription factor CLOCK regulates the transcriptional activity of the glucocorticoid receptor by acetylating its hinge region lysine cluster: potential physiological implications. FASEB J. 2009 May;23(5):1572-83
J:150025 Yoshitane H, et al., Roles of CLOCK phosphorylation in suppression of E-box-dependent transcription. Mol Cell Biol. 2009 Jul;29(13):3675-86
J:154880 Sasaki M, et al., Preferential inhibition of BMAL2-CLOCK activity by PER2 reemphasizes its negative role and a positive role of BMAL2 in the circadian transcription. J Biol Chem. 2009 Sep 11;284(37):25149-59
J:156998 Robles MS, et al., Identification of RACK1 and protein kinase Calpha as integral components of the mammalian circadian clock. Science. 2010 Jan 22;327(5964):463-6
J:157250 Sahar S, et al., Regulation of BMAL1 protein stability and circadian function by GSK3beta-mediated phosphorylation. PLoS One. 2010;5(1):e8561
J:158600 Shi S, et al., Circadian clock gene Bmal1 is not essential; functional replacement with its paralog, Bmal2. Curr Biol. 2010 Feb 23;20(4):316-21
J:162577 Guillaumond F, et al., Kruppel-like factor KLF10 is a link between the circadian clock and metabolism in liver. Mol Cell Biol. 2010 Jun;30(12):3059-70
J:162641 Marcheva B, et al., Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes. Nature. 2010 Jul 29;466(7306):627-31
J:162974 Xu CX, et al., Disruption of CLOCK-BMAL1 transcriptional activity is responsible for aryl hydrocarbon receptor-mediated regulation of Period1 gene. Toxicol Sci. 2010 May;115(1):98-108
J:165365 Doi R, et al., CLOCK regulates circadian rhythms of hepatic glycogen synthesis through transcriptional activation of Gys2. J Biol Chem. 2010 Jul 16;285(29):22114-21
J:166235 Andrews JL, et al., CLOCK and BMAL1 regulate MyoD and are necessary for maintenance of skeletal muscle phenotype and function. Proc Natl Acad Sci U S A. 2010 Nov 2;107(44):19090-5
J:176119 DiTacchio L, et al., Histone lysine demethylase JARID1a activates CLOCK-BMAL1 and influences the circadian clock. Science. 2011 Sep 30;333(6051):1881-5
J:176743 Koyanagi S, et al., cAMP-response element (CRE)-mediated transcription by activating transcription factor-4 (ATF4) is essential for circadian expression of the Period2 gene. J Biol Chem. 2011 Sep 16;286(37):32416-23
J:177241 Ozber N, et al., Identification of two amino acids in the C-terminal domain of mouse CRY2 essential for PER2 interaction. BMC Mol Biol. 2010;11:69
J:177865 Shimba S, et al., Deficient of a clock gene, brain and muscle Arnt-like protein-1 (BMAL1), induces dyslipidemia and ectopic fat formation. PLoS One. 2011;6(9):e25231
J:187450 Guo B, et al., The clock gene, brain and muscle Arnt-like 1, regulates adipogenesis via Wnt signaling pathway. FASEB J. 2012 Aug;26(8):3453-63
J:188853 Huang N, et al., Crystal structure of the heterodimeric CLOCK:BMAL1 transcriptional activator complex. Science. 2012 Jul 13;337(6091):189-94
J:189932 Peruquetti RL, et al., Circadian proteins CLOCK and BMAL1 in the chromatoid body, a RNA processing granule of male germ cells. PLoS One. 2012;7(8):e42695
J:193126 Zhang L, et al., PKCgamma participates in food entrainment by regulating BMAL1. Proc Natl Acad Sci U S A. 2012 Dec 11;109(50):20679-84
J:198047 Li MD, et al., O-GlcNAc signaling entrains the circadian clock by inhibiting BMAL1/CLOCK ubiquitination. Cell Metab. 2013 Feb 5;17(2):303-10
J:198078 Oishi K, et al., The molecular clock regulates circadian transcription of tissue factor gene. Biochem Biophys Res Commun. 2013 Feb 8;431(2):332-5
J:198214 Barclay JL, et al., High-fat diet-induced hyperinsulinemia and tissue-specific insulin resistance in Cry-deficient mice. Am J Physiol Endocrinol Metab. 2013 May 15;304(10):E1053-63
J:201058 Nguyen KD, et al., Circadian gene Bmal1 regulates diurnal oscillations of Ly6C(hi) inflammatory monocytes. Science. 2013 Sep 27;341(6153):1483-8
J:201135 Lande-Diner L, et al., A positive feedback loop links circadian clock factor CLOCK-BMAL1 to the basic transcriptional machinery. Proc Natl Acad Sci U S A. 2013 Oct 1;110(40):16021-16026
J:202325 Hwang CK, et al., Circadian rhythm of contrast sensitivity is regulated by a dopamine-neuronal PAS-domain protein 2-adenylyl cyclase 1 signaling pathway in retinal ganglion cells. J Neurosci. 2013 Sep 18;33(38):14989-97
J:203142 Kennaway DJ, et al., Global loss of bmal1 expression alters adipose tissue hormones, gene expression and glucose metabolism. PLoS One. 2013;8(6):e65255
J:204024 Lee J, et al., Bmal1 and beta-cell clock are required for adaptation to circadian disruption, and their loss of function leads to oxidative stress-induced beta-cell failure in mice. Mol Cell Biol. 2013 Jun;33(11):2327-38
J:205048 Richards J, et al., A role for the circadian clock protein Per1 in the regulation of aldosterone levels and renal Na+ retention. Am J Physiol Renal Physiol. 2013 Dec 15;305(12):F1697-704
J:205584 Menet JS, et al., CLOCK:BMAL1 is a pioneer-like transcription factor. Genes Dev. 2014 Jan 1;28(1):8-13
J:205586 Annayev Y, et al., Gene model 129 (gm129) encodes a novel transcriptional repressor that modulates circadian gene expression. J Biol Chem. 2014 Feb 21;289(8):5013-24
J:206844 Bouchard-Cannon P, et al., The circadian molecular clock regulates adult hippocampal neurogenesis by controlling the timing of cell-cycle entry and exit. Cell Rep. 2013 Nov 27;5(4):961-73
J:206897 Chatterjee S, et al., Brain and muscle Arnt-like 1 is a key regulator of myogenesis. J Cell Sci. 2013 May 15;126(Pt 10):2213-24
J:206952 Khapre RV, et al., BMAL1-dependent regulation of the mTOR signaling pathway delays aging. Aging (Albany NY). 2014 Jan;6(1):48-57
J:207073 Khapre RV, et al., Circadian clock protein BMAL1 regulates cellular senescence in vivo. Cell Cycle. 2011 Dec 1;10(23):4162-9
J:207831 Musiek ES, et al., Circadian clock proteins regulate neuronal redox homeostasis and neurodegeneration. J Clin Invest. 2013 Dec 2;123(12):5389-400
J:209461 Han DH, et al., Modulation of glucocorticoid receptor induction properties by core circadian clock proteins. Mol Cell Endocrinol. 2014 Mar 5;383(1-2):170-80
J:209471 Yoshii K, et al., Effects of NAD(P)H and its derivatives on the DNA-binding activity of NPAS2, a mammalian circadian transcription factor. Biochem Biophys Res Commun. 2013 Aug 2;437(3):386-91
J:209477 Ye R, et al., Biochemical analysis of the canonical model for the mammalian circadian clock. J Biol Chem. 2011 Jul 22;286(29):25891-902
J:209571 Goriki A, et al., A novel protein, CHRONO, functions as a core component of the mammalian circadian clock. PLoS Biol. 2014 Apr;12(4):e1001839
J:211236 Bellet MM, et al., The RelB subunit of NFkappaB acts as a negative regulator of circadian gene expression. Cell Cycle. 2012 Sep 1;11(17):3304-11
J:211243 Ward SM, et al., The transcriptional repressor ID2 can interact with the canonical clock components CLOCK and BMAL1 and mediate inhibitory effects on mPer1 expression. J Biol Chem. 2010 Dec 10;285(50):38987-9000
J:213082 Li DQ, et al., Metastasis-associated protein 1 is an integral component of the circadian molecular machinery. Nat Commun. 2013;4:2545
J:215866 Devos J, et al., Magel2, a Prader-Willi syndrome candidate gene, modulates the activities of circadian rhythm proteins in cultured cells. J Circadian Rhythms. 2011;9(1):12
J:215875 Katada S, et al., The histone methyltransferase MLL1 permits the oscillation of circadian gene expression. Nat Struct Mol Biol. 2010 Dec;17(12):1414-21
J:215957 Stashi E, et al., SRC-2 is an essential coactivator for orchestrating metabolism and circadian rhythm. Cell Rep. 2014 Feb 27;6(4):633-45
J:240095 Shi G, et al., Distinct Roles of HDAC3 in the Core Circadian Negative Feedback Loop Are Critical for Clock Function. Cell Rep. 2016 Feb 02;14(4):823-34
J:244091 Noh JY, et al., Presence of multiple peripheral circadian oscillators in the tissues controlling voiding function in mice. Exp Mol Med. 2014 Mar 07;46:e81
J:244277 Lee J, et al., Loss of Bmal1 leads to uncoupling and impaired glucose-stimulated insulin secretion in beta-cells. Islets. 2011 Nov-Dec;3(6):381-8
J:244448 Somanath PR, et al., Deficiency in core circadian protein Bmal1 is associated with a prothrombotic and vascular phenotype. J Cell Physiol. 2011 Jan;226(1):132-40
J:244832 Zhou B, et al., CLOCK/BMAL1 regulates circadian change of mouse hepatic insulin sensitivity by SIRT1. Hepatology. 2014 Jun;59(6):2196-206
J:250437 Lin R, et al., CLOCK Acetylates ASS1 to Drive Circadian Rhythm of Ureagenesis. Mol Cell. 2017 Oct 5;68(1):198-209.e6
J:262048 Zhang Y, et al., Deubiquitinating enzyme USP9X regulates cellular clock function by modulating the ubiquitination and degradation of a core circadian protein BMAL1. Biochem J. 2018 Apr 30;475(8):1507-1522
J:266073 Toledo M, et al., Autophagy Regulates the Liver Clock and Glucose Metabolism by Degrading CRY1. Cell Metab. 2018 Aug 7;28(2):268-281.e4
J:266297 Dyar KA, et al., Transcriptional programming of lipid and amino acid metabolism by the skeletal muscle circadian clock. PLoS Biol. 2018 Aug;16(8):e2005886
J:267299 Riedel CS, et al., Mice Lacking EGR1 Have Impaired Clock Gene (BMAL1) Oscillation, Locomotor Activity, and Body Temperature. J Mol Neurosci. 2018 Jan;64(1):9-19
J:271270 Deng W, et al., The Circadian Clock Controls Immune Checkpoint Pathway in Sepsis. Cell Rep. 2018 Jul 10;24(2):366-378
J:272534 Lu Y, et al., Cancer/testis antigen PIWIL2 suppresses circadian rhythms by regulating the stability and activity of BMAL1 and CLOCK. Oncotarget. 2017 Aug 15;8(33):54913-54924
J:277685 Petkau N, et al., Acetylation of BMAL1 by TIP60 controls BRD4-P-TEFb recruitment to circadian promoters. Elife. 2019 Jul 11;8:e43235
J:307457 Alvarez JD, et al., The circadian clock protein BMAL1 is necessary for fertility and proper testosterone production in mice. J Biol Rhythms. 2008 Feb;23(1):26-36