Sequence Detail

ID/Version

Q9WTK8 Q9QY57 Q9QZS1 Q9QUK2 Q8VIH6 (UniProt | EBI)

Last sequence update: 2003-04-23
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Meiotic recombination protein SPO11; EC=5.6.2.2 {ECO:0000305};

Provider

SWISS-PROT

Sequence

Polypeptide 396 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Spo11	SPO11 initiator of meiotic double stranded breaks	38	121	3	19

Sequence references in MGI

J:58262 Romanienko PJ, et al., Cloning, characterization, and localization of mouse and human SPO11. Genomics. 1999 Oct 15;61(2):156-69
J:58263 Keeney S, et al., A mouse homolog of the Saccharomyces cerevisiae meiotic recombination DNA transesterase Spo11p. Genomics. 1999 Oct 15;61(2):170-82
J:58910 Shannon M, et al., Differential gene expression of mammalian SPO11/TOP6A homologs during meiosis. FEBS Lett. 1999 Dec 3;462(3):329-34
J:62170 Metzler-Guillemain C, et al., Identification and characterization of an SPO11 homolog in the mouse. Chromosoma. 2000;109(1-2):133-8
J:169057 Kauppi L, et al., Distinct properties of the XY pseudoautosomal region crucial for male meiosis. Science. 2011 Feb 18;331(6019):916-20
J:183411 Fukuda T, et al., Phosphorylation of chromosome core components may serve as axis marks for the status of chromosomal events during mammalian meiosis. PLoS Genet. 2012 Feb;8(2):e1002485
J:229524 Robert T, et al., The TopoVIB-Like protein family is required for meiotic DNA double-strand break formation. Science. 2016 Feb 26;351(6276):943-9