Sequence Detail

ID/Version

Q9WTK7 Q3TAE0 B3VBP0 A0A2L1DGD8 (UniProt | EBI)

Last sequence update: 1999-11-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Serine/threonine-protein kinase STK11 {ECO:0000305}; EC=2.7.11.1 {ECO:0000250|UniProtKB:Q15831};AltName: Full=Liver kinase B1 homolog; Short=LKB1; Short=mLKB1;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 436 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Stk11	serine/threonine kinase 11	167	107	3	30

Sequence references in MGI

J:56026 Luukko K, et al., Expression of LKB1 and PTEN tumor suppressor genes during mouse embryonic development. Mech Dev. 1999 May;83(1-2):187-90
J:56632 Smith DP, et al., The mouse Peutz-Jeghers syndrome gene Lkb1 encodes a nuclear protein kinase. Hum Mol Genet. 1999 Aug;8(8):1479-85
J:60611 Collins SP, et al., LKB1, a novel serine/threonine protein kinase and potential tumour suppressor, is phosphorylated by cAMP-dependent protein kinase (PKA) and prenylated in vivo. Biochem J. 2000 Feb 1;345 Pt 3:673-80
J:70892 Ylikorkala A, et al., Vascular abnormalities and deregulation of VEGF in Lkb1-deficient mice. Science. 2001 Aug 17;293(5533):1323-6
J:76202 Miyoshi H, et al., Gastrointestinal hamartomatous polyposis in Lkb1 heterozygous knockout mice. Cancer Res. 2002 Apr 15;62(8):2261-6
J:77213 Jishage K, et al., Role of Lkb1, the causative gene of Peutz-Jegher's syndrome, in embryogenesis and polyposis. Proc Natl Acad Sci U S A. 2002 Jun 25;99(13):8903-8
J:78818 Bardeesy N, et al., Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation. Nature. 2002 Sep 12;419(6903):162-7
J:79074 Rossi DJ, et al., Induction of cyclooxygenase-2 in a mouse model of Peutz-Jeghers polyposis. Proc Natl Acad Sci U S A. 2002 Sep 17;99(19):12327-32
J:93361 Udd L, et al., Suppression of Peutz-Jeghers polyposis by inhibition of cyclooxygenase-2. Gastroenterology. 2004 Oct;127(4):1030-7
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:104202 Shaw RJ, et al., The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin. Science. 2005 Dec 9;310(5754):1642-6
J:143718 Trost M, et al., The phagosomal proteome in interferon-gamma-activated macrophages. Immunity. 2009 Jan;30(1):143-54
J:143943 Towler MC, et al., A novel short splice variant of the tumour suppressor LKB1 is required for spermiogenesis. Biochem J. 2008 Nov 15;416(1):1-14
J:145786 Denison FC, et al., Characterization of an alternative splice variant of LKB1. J Biol Chem. 2009 Jan 2;284(1):67-76
J:162066 Barnes AP, et al., LKB1 and SAD kinases define a pathway required for the polarization of cortical neurons. Cell. 2007 May 4;129(3):549-63
J:175108 Sapkota GP, et al., Identification and characterization of four novel phosphorylation sites (Ser31, Ser325, Thr336 and Thr366) on LKB1/STK11, the protein kinase mutated in Peutz-Jeghers cancer syndrome. Biochem J. 2002 Mar 1;362(Pt 2):481-90
J:175116 Sapkota GP, et al., Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell vrowth. J Biol Chem. 2001 Jun 1;276(22):19469-82
J:175207 Sapkota GP, et al., Ionizing radiation induces ataxia telangiectasia mutated kinase (ATM)-mediated phosphorylation of LKB1/STK11 at Thr-366. Biochem J. 2002 Dec 1;368(Pt 2):507-16
J:180573 Lan F, et al., SIRT1 modulation of the acetylation status, cytosolic localization, and activity of LKB1. Possible role in AMP-activated protein kinase activation. J Biol Chem. 2008 Oct 10;283(41):27628-35
J:217430 Esteve-Puig R, et al., A mouse model uncovers LKB1 as an UVB-induced DNA damage sensor mediating CDKN1A (p21WAF1/CIP1) degradation. PLoS Genet. 2014 Oct;10(10):e1004721
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89