Sequence Detail

ID/Version

Q9WTK2 Q6P6N3 Q3U0W2 (UniProt | EBI)

Last sequence update: 1999-11-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Chromodomain Y-like protein {ECO:0000303|PubMed:10192397}; Short=CDY-like {ECO:0000303|PubMed:10192397};AltName: Full=Crotonyl-CoA hydratase {ECO:0000250|UniProtKB:Q9Y232}; EC=4.2.1.- {ECO:0000250|UniProtKB:Q9Y232};AltName: F

Provider

SWISS-PROT

Sequence

Polypeptide 593 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Cdyl	chromodomain protein, Y chromosome-like	37	99	3	57

Sequence references in MGI

J:51454 Lahn BT, et al., Retroposition of autosomal mRNA yielded testis-specific gene family on human Y chromosome [published erratum appears in Nat Genet 1999 Jun;22(2):209]. Nat Genet. 1999 Apr;21(4):429-33
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:206754 Escamilla-Del-Arenal M, et al., Cdyl, a new partner of the inactive X chromosome and potential reader of H3K27me3 and H3K9me2. Mol Cell Biol. 2013 Dec;33(24):5005-20
J:250430 Liu S, et al., Chromodomain Protein CDYL Acts as a Crotonyl-CoA Hydratase to Regulate Histone Crotonylation and Spermatogenesis. Mol Cell. 2017 Sep 7;67(5):853-866.e5
J:251551 Qin R, et al., CDYL Deficiency Disrupts Neuronal Migration and Increases Susceptibility to Epilepsy. Cell Rep. 2017 Jan 10;18(2):380-390
J:252750 Liu Y, et al., CDYL suppresses epileptogenesis in mice through repression of axonal Nav1.6 sodium channel expression. Nat Commun. 2017 Aug 25;8(1):355
J:277855 Parvanov ED, et al., PRDM9 interactions with other proteins provide a link between recombination hotspots and the chromosomal axis in meiosis. Mol Biol Cell. 2017 Feb 1;28(3):488-499
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:298786 Liu Y, et al., Chromodomain Y-like Protein-Mediated Histone Crotonylation Regulates Stress-Induced Depressive Behaviors. Biol Psychiatry. 2019 Apr 15;85(8):635-649