Sequence Detail

ID/Version

Q9R207 O88981 Q9R1X1 Q3UY57 Q811I6 Q8CCY0 (UniProt | EBI)

Last sequence update: 2000-05-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Nibrin {ECO:0000303|PubMed:10640816};AltName: Full=Cell cycle regulatory protein p95;AltName: Full=Nijmegen breakage syndrome protein 1 homolog {ECO:0000303|PubMed:10640816};

Provider

SWISS-PROT

Sequence

Polypeptide 751 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Nbn	nibrin	135	103	3	37

Sequence references in MGI

J:59119 Vissinga CS, et al., Identification, characterization, and mapping of a mouse homolog of the gene mutated in Nijmegen breakage syndrome. Cytogenet Cell Genet. 1999;87(1-2):80-4
J:63741 Wilda M, et al., Expression pattern of the nijmegen breakage syndrome gene, nbs1, during murine development. Hum Mol Genet. 2000 Jul 22;9(12):1739-44
J:68993 Zhu J, et al., Targeted disruption of the Nijmegen breakage syndrome gene NBS1 leads to early embryonic lethality in mice. Curr Biol. 2001 Jan 23;11(2):105-9
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:120745 Cherry SM, et al., The Mre11 complex influences DNA repair, synapsis, and crossing over in murine meiosis. Curr Biol. 2007 Feb 20;17(4):373-8
J:122564 Yong W, et al., Mice lacking protein phosphatase 5 are defective in ataxia telangiectasia mutated (ATM)-mediated cell cycle arrest. J Biol Chem. 2007 May 18;282(20):14690-4
J:188027 Wu J, et al., Skp2 E3 ligase integrates ATM activation and homologous recombination repair by ubiquitinating NBS1. Mol Cell. 2012 May 11;46(3):351-61
J:265834 Hung PJ, et al., MRI Is a DNA Damage Response Adaptor during Classical Non-homologous End Joining. Mol Cell. 2018 Jul 19;71(2):332-342.e8
J:267805 Rai R, et al., NBS1 Phosphorylation Status Dictates Repair Choice of Dysfunctional Telomeres. Mol Cell. 2017 Mar 2;65(5):801-817.e4
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89