Sequence Detail

ID/Version

Q9R1Y5 Q9R2B0 B1ARH0 Q9R1Y6 (UniProt | EBI)

Last sequence update: 2011-12-14
Last annotation update: 2024-01-24

Sequence description from provider

RecName: Full=Hypermethylated in cancer 1 protein; Short=Hic-1;

Provider

SWISS-PROT

Sequence

Polypeptide 733 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Hic1	hypermethylated in cancer 1	25	110	3	12

Sequence references in MGI

J:54410 Grimm C, et al., Isolation and embryonic expression of the novel mouse gene Hic1, the homologue of HIC1, a candidate gene for the Miller-Dieker syndrome. Hum Mol Genet. 1999 Apr;8(4):697-710
J:60589 Carter MG, et al., Mice deficient in the candidate tumor suppressor gene Hic1 exhibit developmental defects of structures affected in the Miller-Dieker syndrome. Hum Mol Genet. 2000 Feb 12;9(3):413-9
J:67295 Guerardel C, et al., Identification in the human candidate tumor suppressor gene HIC-1 of a new major alternative TATA-less promoter positively regulated by p53. J Biol Chem. 2001 Feb 2;276(5):3078-89
J:81448 Chen WY, et al., Heterozygous disruption of Hic1 predisposes mice to a gender-dependent spectrum of malignant tumors. Nat Genet. 2003 Feb;33(2):197-202
J:132980 Briggs KJ, et al., Cooperation between the Hic1 and Ptch1 tumor suppressors in medulloblastoma. Genes Dev. 2008 Mar 15;22(6):770-85
J:178278 Chen WY, et al., Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses. Cell. 2005 Nov 4;123(3):437-48
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:306378 Guo A, et al., Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. Mol Cell Proteomics. 2014 Jan;13(1):372-87