Sequence Detail

ID/Version

Q9R1X4 Q6PDL4 Q6P204 Q8R0Q2 Q63ZX9 Q7TPV8 Q9R268 Q9Z0E7 (UniProt | EBI)

Last sequence update: 2005-03-15
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Protein timeless homolog; Short=mTim;

Provider

SWISS-PROT

Sequence

Polypeptide 1197 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Timeless	timeless circadian clock 1	70	117	3	37

Sequence references in MGI

J:51391 Zylka MJ, et al., Molecular analysis of mammalian timeless. Neuron. 1998 Nov;21(5):1115-22
J:51392 Sangoram AM, et al., Mammalian circadian autoregulatory loop: a timeless ortholog and mPer1 interact and negatively regulate CLOCK-BMAL1-induced transcription. Neuron. 1998 Nov;21(5):1101-13
J:51960 Koike N, et al., Identification of the mammalian homologues of the Drosophila timeless gene, Timeless1. FEBS Lett. 1998 Dec 28;441(3):427-31
J:57184 Takumi T, et al., A mammalian ortholog of Drosophila timeless, highly expressed in SCN and retina, forms a complex with mPER1. Genes Cells. 1999 Jan;4(1):67-75
J:64379 Li Z, et al., A role for timeless in epithelial morphogenesis during kidney development. Proc Natl Acad Sci U S A. 2000 Aug 29;97(18):10038-43
J:84659 Gotter AL, Tipin, a novel timeless-interacting protein, is developmentally co-expressed with timeless and disrupts its self-association. J Mol Biol. 2003 Aug 1;331(1):167-76
J:209425 Kang TH, et al., Modulation of ATR-mediated DNA damage checkpoint response by cryptochrome 1. Nucleic Acids Res. 2014 Apr;42(7):4427-34
J:212062 Engelen E, et al., Mammalian TIMELESS is involved in period determination and DNA damage-dependent phase advancing of the circadian clock. PLoS One. 2013;8(2):e56623
J:276566 Kurien P, et al., TIMELESS mutation alters phase responsiveness and causes advanced sleep phase. Proc Natl Acad Sci U S A. 2019 Jun 11;116(24):12045-12053
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89