Sequence Detail

ID/Version

Q9R1V6 Q5TLJ1 Q5TLJ2 Q9R1V5 Q5TLJ5 Q5TLK8 Q5TLJ3 Q5TLI8 Q5TLJ6 Q5TLK0 Q5TLK4 Q5TLJ0 Q5TLJ7 Q8BSF2 Q5TLI9 Q5TLK1 Q5TLK6 Q5TLK3 Q5TLK7 Q5TLJ4 Q5TLJ8 Q5TLJ9 Q5TLK5 Q5TLK2 (UniProt | EBI)

Last sequence update: 2006-05-02
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Disintegrin and metalloproteinase domain-containing protein 22; Short=ADAM 22;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 904 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Adam22	a disintegrin and metallopeptidase domain 22	34	99	3	12

Sequence references in MGI

J:56924 Sagane K, et al., Cloning and chromosomal mapping of mouse ADAM11, ADAM22 and ADAM23. Gene. 1999 Aug 5;236(1):79-86
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:99692 Sagane K, et al., Ataxia and peripheral nerve hypomyelination in ADAM22-deficient mice. BMC Neurosci. 2005 May 6;6(1):33
J:112818 Fukata Y, et al., Epilepsy-related ligand/receptor complex LGI1 and ADAM22 regulate synaptic transmission. Science. 2006 Sep 22;313(5794):1792-5
J:153391 Sagane K, et al., LGI1 and LGI4 bind to ADAM22, ADAM23 and ADAM11. Int J Biol Sci. 2008;4(6):387-96
J:157696 Ogawa Y, et al., ADAM22, a Kv1 channel-interacting protein, recruits membrane-associated guanylate kinases to juxtaparanodes of myelinated axons. J Neurosci. 2010 Jan 20;30(3):1038-48
J:226018 Kole MJ, et al., Selective Loss of Presynaptic Potassium Channel Clusters at the Cerebellar Basket Cell Terminal Pinceau in Adam11 Mutants Reveals Their Role in Ephaptic Control of Purkinje Cell Firing. J Neurosci. 2015 Aug 12;35(32):11433-44
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89