Sequence Detail

ID/Version

Q9R1M5 Q6VSF9 Q9JLR2 Q6VSG0 Q6VSG5 Q7TPU9 Q6XZF2 Q6VSG3 Q3UXD0 Q6VSG4 Q6VSG1 Q53ZD5 Q6VSG2 (UniProt | EBI)

Last sequence update: 2007-05-01
Last annotation update: 2025-06-18

Sequence description from provider

RecName: Full=NACHT, LRR and PYD domains-containing protein 5 {ECO:0000305};AltName: Full=Maternal antigen that embryos require {ECO:0000303|PubMed:10754103}; Short=Mater protein {ECO:0000303|PubMed:10754103};AltName: Full=Ooplasm-specific protein

Provider

SWISS-PROT

Sequence

Polypeptide 1163 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Nlrp5	NLR family, pyrin domain containing 5	65	124	11	6

Sequence references in MGI

J:56809 Tong ZB, et al., A mouse gene encoding an oocyte antigen associated with autoimmune premature ovarian failure [see comments]. Endocrinology. 1999 Aug;140(8):3720-6
J:61078 Tong ZB, et al., Mater encodes a maternal protein in mice with a leucine-rich repeat domain homologous to porcine ribonuclease inhibitor. Mamm Genome. 2000 Apr;11(4):281-7
J:65518 Tong ZB, et al., Mater, a maternal effect gene required for early embryonic development in mice. Nat Genet. 2000 Nov;26(3):267-8
J:78005 Roper RJ, et al., Interacting quantitative trait loci control loss of peripheral tolerance and susceptibility to autoimmune ovarian dysgenesis after day 3 thymectomy in mice. J Immunol. 2002 Aug 1;169(3):1640-6
J:88687 Tong ZB, et al., Developmental expression and subcellular localization of mouse MATER, an oocyte-specific protein essential for early development. Endocrinology. 2004 Mar;145(3):1427-34
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:130427 Ohsugi M, et al., Maternally derived FILIA-MATER complex localizes asymmetrically in cleavage-stage mouse embryos. Development. 2008 Jan;135(2):259-69
J:140105 Li L, et al., A subcortical maternal complex essential for preimplantation mouse embryogenesis. Dev Cell. 2008 Sep;15(3):416-25
J:185833 Fernandes R, et al., NLRP5 mediates mitochondrial function in mouse oocytes and embryos. Biol Reprod. 2012;86(5):138, 1-10
J:206880 Kim B, et al., The role of MATER in endoplasmic reticulum distribution and calcium homeostasis in mouse oocytes. Dev Biol. 2014 Feb 15;386(2):331-9
J:276268 Yu XJ, et al., The subcortical maternal complex controls symmetric division of mouse zygotes by regulating F-actin dynamics. Nat Commun. 2014 Sep 11;5:4887
J:278740 Vogt EJ, et al., Anchoring cortical granules in the cortex ensures trafficking to the plasma membrane for post-fertilization exocytosis. Nat Commun. 2019 May 22;10(1):2271
J:284116 Qin D, et al., The subcortical maternal complex protein Nlrp4f is involved in cytoplasmic lattice formation and organelle distribution. Development. 2019 Oct 18;146(20):dev183616
J:296111 Gao Z, et al., Zbed3 participates in the subcortical maternal complex and regulates the distribution of organelles. J Mol Cell Biol. 2018 Feb 1;10(1):74-88
J:342673 Jentoft IMA, et al., Mammalian oocytes store proteins for the early embryo on cytoplasmic lattices. Cell. 2023 Oct 30;
J:362046 Chi P, et al., Structural basis of the subcortical maternal complex and its implications in reproductive disorders. Nat Struct Mol Biol. 2024 Jan;31(1):115-124