Sequence Detail

ID/Version

Q9R1J0 O55109 (UniProt | EBI)

Last sequence update: 2000-05-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating; EC=1.1.1.170 {ECO:0000269|PubMed:10369263, ECO:0000269|PubMed:14567972};

Provider

SWISS-PROT

Sequence

Polypeptide 362 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Nsdhl	NAD(P) dependent steroid dehydrogenase-like	32	106	3	20

Sequence references in MGI

J:55488 Liu XY, et al., The gene mutated in bare patches and striated mice encodes a novel 3beta-hydroxysteroid dehydrogenase. Nat Genet. 1999 Jun;22(2):182-7
J:62786 Mallon AM, et al., Comparative genome sequence analysis of the Bpa/Str region in mouse and Man. Genome Res. 2000 Jun;10(6):758-75
J:100224 Lucas ME, et al., Identification of two novel mutations in the murine Nsdhl sterol dehydrogenase gene and development of a functional complementation assay in yeast. Mol Genet Metab. 2003 Sep-Oct;80(1-2):227-33
J:194123 Sukhanova A, et al., Targeting C4-demethylating genes in the cholesterol pathway sensitizes cancer cells to EGF receptor inhibitors via increased EGF receptor degradation. Cancer Discov. 2013 Jan;3(1):96-111
J:289089 Caldas H, et al., NSDHL, an enzyme involved in cholesterol biosynthesis, traffics through the Golgi and accumulates on ER membranes and on the surface of lipid droplets. Hum Mol Genet. 2003 Nov 15;12(22):2981-91
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89