Sequence Detail

ID/Version

Q9R117 Q8VE41 Q52KQ2 O88431 Q3TXE3 (UniProt | EBI)

Last sequence update: 2018-01-31
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Non-receptor tyrosine-protein kinase TYK2; EC=2.7.10.2;

Provider

SWISS-PROT

Sequence

Polypeptide 1184 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Tyk2	tyrosine kinase 2	73	96	3	19

Sequence references in MGI

J:65408 Karaghiosoff M, et al., Partial impairment of cytokine responses in Tyk2-deficient mice. Immunity. 2000 Oct;13(4):549-60
J:65409 Shimoda K, et al., Tyk2 plays a restricted role in IFN alpha signaling, although it is required for IL-12-mediated T cell function. Immunity. 2000 Oct;13(4):561-71
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:193351 Zhang X, et al., Docking protein Gab2 regulates mucin expression and goblet cell hyperplasia through TYK2/STAT6 pathway. FASEB J. 2012 Nov;26(11):4603-13
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89