Sequence Detail

ID/Version

Q9R0Q8 (UniProt | EBI)

Last sequence update: 2000-05-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=C-type lectin domain family 4 member E;AltName: Full=C-type lectin superfamily member 9;AltName: Full=Macrophage-inducible C-type lectin {ECO:0000303|PubMed:18776906}; Short=Mincle {ECO:0000303|PubMed:18776906, ECO:0000303|PubMed:191

Provider

SWISS-PROT

Sequence

Polypeptide 214 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Clec4e	C-type lectin domain family 4, member e	12	96	2	14

Sequence references in MGI

J:63533 Matsumoto M, et al., A novel LPS-inducible C-type lectin is a transcriptional target of NF-IL6 in macrophages. J Immunol. 1999 Nov 1;163(9):5039-48
J:136334 Wells CA, et al., The macrophage-inducible C-type lectin, mincle, is an essential component of the innate immune response to Candida albicans. J Immunol. 2008 Jun 1;180(11):7404-13
J:141143 Yamasaki S, et al., Mincle is an ITAM-coupled activating receptor that senses damaged cells. Nat Immunol. 2008 Oct;9(10):1179-88
J:155670 Ishikawa E, et al., Direct recognition of the mycobacterial glycolipid, trehalose dimycolate, by C-type lectin Mincle. J Exp Med. 2009 Dec 21;206(13):2879-88
J:172959 Yamasaki S, et al., C-type lectin Mincle is an activating receptor for pathogenic fungus, Malassezia. Proc Natl Acad Sci U S A. 2009 Feb 10;106(6):1897-902
J:203159 Miyake Y, et al., C-type lectin MCL is an FcRgamma-coupled receptor that mediates the adjuvanticity of mycobacterial cord factor. Immunity. 2013 May 23;38(5):1050-62