Sequence Detail

ID/Version

Q9R0N7 Q8CF95 Q0D2K7 E9PZA8 A4QPF1 Q8CF96 (UniProt | EBI)

Last sequence update: 2000-05-01
Last annotation update: 2025-06-18

Sequence description from provider

RecName: Full=Synaptotagmin-7 {ECO:0000305};AltName: Full=Synaptotagmin VII {ECO:0000303|PubMed:10531343}; Short=SytVII {ECO:0000303|PubMed:10531343};

Provider

SWISS-PROT

Sequence

Polypeptide 403 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Syt7	synaptotagmin VII	94	98	4	15

Sequence references in MGI

J:62060 Fukuda M, et al., Conserved N-terminal cysteine motif is essential for homo- and heterodimer formation of synaptotagmins III, V, VI, and X. J Biol Chem. 1999 Oct 29;274(44):31421-7
J:69628 Sugita S, et al., Synaptotagmin VII as a plasma membrane Ca(2+) sensor in exocytosis. Neuron. 2001 May;30(2):459-73
J:85201 Chakrabarti S, et al., Impaired membrane resealing and autoimmune myositis in synaptotagmin VII-deficient mice. J Cell Biol. 2003 Aug 18;162(4):543-9
J:115013 Czibener C, et al., Ca2+ and synaptotagmin VII-dependent delivery of lysosomal membrane to nascent phagosomes. J Cell Biol. 2006 Sep 25;174(7):997-1007
J:131422 Gustavsson N, et al., Impaired insulin secretion and glucose intolerance in synaptotagmin-7 null mutant mice. Proc Natl Acad Sci U S A. 2008 Mar 11;105(10):3992-7
J:137198 Zhao H, et al., Synaptotagmin VII regulates bone remodeling by modulating osteoclast and osteoblast secretion. Dev Cell. 2008 Jun;14(6):914-25
J:166232 Segovia M, et al., Push-and-pull regulation of the fusion pore by synaptotagmin-7. Proc Natl Acad Sci U S A. 2010 Nov 2;107(44):19032-7
J:166575 Gustavsson N, et al., Synaptotagmin-7 is a principal Ca2+ sensor for Ca2+ -induced glucagon exocytosis in pancreas. J Physiol. 2009 Mar 15;587(Pt 6):1169-78
J:166710 Flannery AR, et al., Palmitoylation-dependent association with CD63 targets the Ca2+ sensor synaptotagmin VII to lysosomes. J Cell Biol. 2010 Nov 1;191(3):599-613
J:207968 Liu H, et al., Synaptotagmin 7 functions as a Ca2+-sensor for synaptic vesicle replenishment. Elife. 2014;3:e01524
J:222860 Chu BB, et al., Cholesterol transport through lysosome-peroxisome membrane contacts. Cell. 2015 Apr 9;161(2):291-306
J:228494 Jackman SL, et al., The calcium sensor synaptotagmin 7 is required for synaptic facilitation. Nature. 2016 Jan 7;529(7584):88-91
J:268351 Barthet G, et al., Presenilin-mediated cleavage of APP regulates synaptotagmin-7 and presynaptic plasticity. Nat Commun. 2018 Nov 14;9(1):4780
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:306378 Guo A, et al., Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. Mol Cell Proteomics. 2014 Jan;13(1):372-87