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Sequence Detail
Q9R0N6 Q8C6E7 Q64366 A9JAL0 (UniProt | EBI) Last sequence update: 2000-05-01
Last annotation update: 2020-04-22
from provider
RecName: Full=Synaptotagmin-8;AltName: Full=Synaptotagmin VIII; Short=SytVIII;
Polypeptide 395 aa
For this sequence
Organism mouse
See UniProt | EBI for source
Annotated genes and markers Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.
Type Symbol Name GO Terms Expression
Orthologs Phenotypic
Gene Syt8 synaptotagmin VIII 32 71 6 3
Sequence references in MGI J:26068 Li C, et al., Ca(2+)-dependent and -independent activities of neural and non-neural synaptotagmins. Nature. 1995 Jun 15;375(6532):594-9
J:62060 Fukuda M, et al., Conserved N-terminal cysteine motif is essential for homo- and heterodimer formation of synaptotagmins III, V, VI, and X. J Biol Chem. 1999 Oct 29;274(44):31421-7
J:64914 Mizutani A, et al., SYNCRIP, a cytoplasmic counterpart of heterogeneous nuclear ribonucleoprotein R, interacts with ubiquitous synaptotagmin isoforms. J Biol Chem. 2000 Mar 31;275(13):9823-31
J:74013 Hutt DM, et al., Synaptotagmin VIII is localized to the mouse sperm head and may function in acrosomal exocytosis. Biol Reprod. 2002 Jan;66(1):50-6
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:99919 Hutt DM, et al., Synaptotagmin VI and VIII and syntaxin 2 are essential for the mouse sperm acrosome reaction. J Biol Chem. 2005 May 27;280(21):20197-203
J:169902 Monterrat C, et al., Synaptotagmin 8 is expressed both as a calcium-insensitive soluble and membrane protein in neurons, neuroendocrine and endocrine cells. Biochim Biophys Acta. 2006 Jan;1763(1):73-81

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory