Sequence Detail

ID/Version

Q9R0A1 Q9WUJ9 Q0VBC2 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Chloride channel protein 2; Short=ClC-2;

Provider

SWISS-PROT

Sequence

Polypeptide 908 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Clcn2	chloride channel, voltage-sensitive 2	78	102	5	17

Sequence references in MGI

J:57459 Joo NS, et al., Cloning of ClC-2 chloride channel from murine duodenum and its presence in CFTR knockout mice. Biochim Biophys Acta. 1999 Sep 3;1446(3):431-7
J:102196 Pena-Munzenmayer G, et al., Basolateral localization of native ClC-2 chloride channels in absorptive intestinal epithelial cells and basolateral sorting encoded by a CBS-2 domain di-leucine motif. J Cell Sci. 2005 Sep 15;118(Pt 18):4243-52
J:122365 Blanz J, et al., Leukoencephalopathy upon disruption of the chloride channel ClC-2. J Neurosci. 2007 Jun 13;27(24):6581-9
J:142744 Romanenko VG, et al., Clcn2 encodes the hyperpolarization-activated chloride channel in the ducts of mouse salivary glands. Am J Physiol Gastrointest Liver Physiol. 2008 Nov;295(5):G1058-67
J:159381 Rinke I, et al., ClC-2 voltage-gated channels constitute part of the background conductance and assist chloride extrusion. J Neurosci. 2010 Mar 31;30(13):4776-86
J:182668 Jeworutzki E, et al., GlialCAM, a protein defective in a leukodystrophy, serves as a ClC-2 Cl(-) channel auxiliary subunit. Neuron. 2012 Mar 8;73(5):951-61
J:260989 Fernandes-Rosa FL, et al., A gain-of-function mutation in the CLCN2 chloride channel gene causes primary aldosteronism. Nat Genet. 2018 Mar;50(3):355-361
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:347331 De Jesus-Perez JJ, et al., Gating the glutamate gate of CLC-2 chloride channel by pore occupancy. J Gen Physiol. 2016 Jan;147(1):25-37