Sequence Detail

ID/Version

Q9QZR5 Q9D474 Q99P46 Q99P45 O88905 Q9EQL2 Q9QZR4 Q9D2E6 (UniProt | EBI)

Last sequence update: 2001-04-27
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Homeodomain-interacting protein kinase 2; EC=2.7.11.1 {ECO:0000269|PubMed:11780126};AltName: Full=Nuclear body-associated kinase 1;AltName: Full=Sialophorin tail-associated nuclear serine/threonine-protein kinase;

Provider

SWISS-PROT

Sequence

Polypeptide 1196 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Hipk2	homeodomain interacting protein kinase 2	130	109	3	20

Sequence references in MGI

J:50387 Kim YH, et al., Homeodomain-interacting protein kinases, a novel family of co-repressors for homeodomain transcription factors. J Biol Chem. 1998 Oct 2;273(40):25875-9
J:65841 Wang W, et al., Identification and cloning of a CD43-associated Serine/Threonine kinase. Cell Immunol. 2000 Oct 10;205(1):34-9
J:68363 Wang Y, et al., Isolation and characterization of cDNAs for the protein kinase HIPK2. Biochim Biophys Acta. 2001 Mar 19;1518(1-2):168-72
J:74769 Pierantoni GM, et al., The homeodomain-interacting protein kinase 2 gene is expressed late in embryogenesis and preferentially in retina, muscle, and neural tissues. Biochem Biophys Res Commun. 2002 Jan 25;290(3):942-7
J:86139 Zhang Q, et al., Homeodomain interacting protein kinase 2 promotes apoptosis by downregulating the transcriptional corepressor CtBP. Cell. 2003 Oct 17;115(2):177-86
J:88822 Giraud S, et al., US11 of herpes simplex virus type 1 interacts with HIPK2 and antagonizes HIPK2-induced cell growth arrest. J Virol. 2004 Mar;78(6):2984-93
J:89440 Kanei-Ishii C, et al., Wnt-1 signal induces phosphorylation and degradation of c-Myb protein via TAK1, HIPK2, and NLK. Genes Dev. 2004 Apr 1;18(7):816-29
J:93311 Wiggins AK, et al., Interaction of Brn3a and HIPK2 mediates transcriptional repression of sensory neuron survival. J Cell Biol. 2004 Nov 25;167(2):257-67
J:94782 Rui Y, et al., Axin stimulates p53 functions by activation of HIPK2 kinase through multimeric complex formation. EMBO J. 2004 Nov 24;23(23):4583-94
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:112873 Aikawa Y, et al., Roles of HIPK1 and HIPK2 in AML1- and p300-dependent transcription, hematopoiesis and blood vessel formation. EMBO J. 2006 Sep 6;25(17):3955-65
J:162323 Inoue T, et al., Involvement of the Hipk family in regulation of eyeball size, lens formation and retinal morphogenesis. FEBS Lett. 2010 Jul 16;584(14):3233-8
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89