Sequence Detail

ID/Version

Q9QZQ8 Q91VZ2 Q9QZQ7 (UniProt | EBI)

Last sequence update: 2022-10-12
Last annotation update: 2024-01-24

Sequence description from provider

RecName: Full=Core histone macro-H2A.1; Short=Histone macroH2A1; Short=mH2A1;AltName: Full=H2A.y;AltName: Full=H2A/y;

Provider

SWISS-PROT

Sequence

Polypeptide 369 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Macroh2a1	macroH2A.1 histone	81	117	3	37

Sequence references in MGI

J:48057 Costanzi C, et al., Histone macroH2A1 is concentrated in the inactive X chromosome of female mammals. Nature. 1998 Jun 11;393(6685):599-601
J:57665 Rasmussen TP, et al., Messenger RNAs encoding mouse histone macroH2A1 isoforms are expressed at similar levels in male and female cells and result from alternative splicing. Nucleic Acids Res. 1999 Sep 15;27(18):3685-9
J:69970 Costanzi C, et al., MACROH2A2, a new member of the MARCOH2A core histone family. J Biol Chem. 2001 Jun 15;276(24):21776-84
J:94239 Grigoryev SA, et al., Dynamic relocation of epigenetic chromatin markers reveals an active role of constitutive heterochromatin in the transition from proliferation to quiescence. J Cell Sci. 2004 Dec 1;117(Pt 25):6153-62
J:143718 Trost M, et al., The phagosomal proteome in interferon-gamma-activated macrophages. Immunity. 2009 Jan;30(1):143-54
J:203468 Park J, et al., SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. Mol Cell. 2013 Jun 27;50(6):919-30
J:238450 Dardenne E, et al., Splicing switch of an epigenetic regulator by RNA helicases promotes tumor-cell invasiveness. Nat Struct Mol Biol. 2012 Nov;19(11):1139-46
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:325974 Posavec Marjanovic M, et al., MacroH2A1.1 regulates mitochondrial respiration by limiting nuclear NAD(+) consumption. Nat Struct Mol Biol. 2017 Nov;24(11):902-910