Sequence Detail

ID/Version

Q9QZH6 Q91V53 (UniProt | EBI)

Last sequence update: 2007-06-26
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial {ECO:0000305};AltName: Full=Protein SITPEC;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 435 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Ecsit	ECSIT signalling integrator	38	98	3	9

Sequence references in MGI

J:57233 Kopp E, et al., ECSIT is an evolutionarily conserved intermediate in the Toll/IL-1 signal transduction pathway. Genes Dev. 1999 Aug 15;13(16):2059-71
J:86912 Xiao C, et al., Ecsit is required for Bmp signaling and mesoderm formation during mouse embryogenesis. Genes Dev. 2003 Dec 1;17(23):2933-49
J:184896 Kondo T, et al., TRIM59 interacts with ECSIT and negatively regulates NF-kappaB and IRF-3/7-mediated signal pathways. Biochem Biophys Res Commun. 2012 Jun 8;422(3):501-7
J:271638 Carneiro FRG, et al., An Essential Role for ECSIT in Mitochondrial Complex I Assembly and Mitophagy in Macrophages. Cell Rep. 2018 Mar 6;22(10):2654-2666
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89