Sequence Detail

ID/Version

Q9QZB6 Q9QZB5 (UniProt | EBI)

Last sequence update: 2000-05-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Nuclear receptor subfamily 4 group A member 3;AltName: Full=Orphan nuclear receptor TEC;AltName: Full=Translocated in extraskeletal chondrosarcoma;

Provider

SWISS-PROT

Sequence

Polypeptide 627 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Nr4a3	nuclear receptor subfamily 4, group A, member 3	105	124	3	13

Sequence references in MGI

J:60555 Maltais A, et al., Structure and expression of the mouse gene encoding the orphan nuclear receptor TEC. DNA Cell Biol. 2000 Feb;19(2):121-30
J:73971 Ponnio T, et al., The nuclear receptor Nor-1 is essential for proliferation of the semicircular canals of the mouse inner ear. Mol Cell Biol. 2002 Feb;22(3):935-45
J:89944 DeYoung RA, et al., The orphan steroid receptor Nur77 family member Nor-1 is essential for early mouse embryogenesis. J Biol Chem. 2003 Nov 21;278(47):47104-9
J:93320 Ponnio T, et al., nor-1 Regulates Hippocampal Axon Guidance, Pyramidal Cell Survival, and Seizure Susceptibility. Mol Cell Biol. 2004 Nov;24(20):9070-8
J:151527 Nonogaki K, et al., Serotonin 5-HT2C receptor-independent expression of hypothalamic NOR1, a novel modulator of food intake and energy balance, in mice. Biochem Biophys Res Commun. 2009 Aug 21;386(2):311-5
J:162076 Volakakis N, et al., NR4A orphan nuclear receptors as mediators of CREB-dependent neuroprotection. Proc Natl Acad Sci U S A. 2010 Jul 6;107(27):12317-22
J:165911 Nomiyama T, et al., Deficiency of the NR4A neuron-derived orphan receptor-1 attenuates neointima formation after vascular injury. Circulation. 2009 Feb 3;119(4):577-86
J:175040 Zhao Y, et al., Deficiency of the NR4A orphan nuclear receptor NOR1 decreases monocyte adhesion and atherosclerosis. Circ Res. 2010 Aug 20;107(4):501-11
J:177579 Gizard F, et al., Transcriptional regulation of S phase kinase-associated protein 2 by NR4A orphan nuclear receptor NOR1 in vascular smooth muscle cells. J Biol Chem. 2011 Oct 14;286(41):35485-93
J:205020 Kim SG, et al., Control of energy balance by hypothalamic gene circuitry involving two nuclear receptors, neuron-derived orphan receptor 1 and glucocorticoid receptor. Mol Cell Biol. 2013 Oct;33(19):3826-34
J:213833 Garcia-Faroldi G, et al., Nuclear receptor 4a3 (nr4a3) regulates murine mast cell responses and granule content. PLoS One. 2014;9(2):e89311
J:216777 Qing H, et al., Deficiency of the NR4A orphan nuclear receptor NOR1 in hematopoietic stem cells accelerates atherosclerosis. Stem Cells. 2014 Sep;32(9):2419-29
J:222681 Chao LC, et al., Inhibition of adipocyte differentiation by Nur77, Nurr1, and Nor1. Mol Endocrinol. 2008 Dec;22(12):2596-608
J:222682 Pearen MA, et al., The orphan nuclear receptor, NOR-1, a target of beta-adrenergic signaling, regulates gene expression that controls oxidative metabolism in skeletal muscle. Endocrinology. 2008 Jun;149(6):2853-65
J:222684 Wansa KD, et al., The AF-1 domain of the orphan nuclear receptor NOR-1 mediates trans-activation, coactivator recruitment, and activation by the purine anti-metabolite 6-mercaptopurine. J Biol Chem. 2003 Jul 4;278(27):24776-90