Sequence Detail

ID/Version

Q9QZ28 O88423 (UniProt | EBI)

Last sequence update: 2002-06-01
Last annotation update: 2025-06-18

Sequence description from provider

RecName: Full=Homeobox protein SIX6;AltName: Full=Optic homeobox 2;AltName: Full=Sine oculis homeobox homolog 6;AltName: Full=Six9 protein;

Provider

SWISS-PROT

Sequence

Polypeptide 246 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Six6	sine oculis-related homeobox 6	18	138	4	5

Sequence references in MGI

J:55598 Toy J, et al., The optx2 homeobox gene is expressed in early precursors of the eye and activates retina-specific genes. Proc Natl Acad Sci U S A. 1998 Sep 1;95(18):10643-8
J:56024 Lopez-Rios J, et al., Six9 (Optx2), a new member of the six gene family of transcription factors, is expressed at early stages of vertebrate ocular and pituitary development. Mech Dev. 1999 May;83(1-2):155-9
J:56368 Jean D, et al., Six6 (Optx2) is a novel murine Six3-related homeobox gene that demarcates the presumptive pituitary/hypothalamic axis and the ventral optic stalk. Mech Dev. 1999 Jun;84(1-2):31-40
J:77680 Zhu CC, et al., Six3-mediated auto repression and eye development requires its interaction with members of the Groucho-related family of co-repressors. Development. 2002 Jun;129(12):2835-49
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563