Sequence Detail

ID/Version

Q9QZ05 A2AUM4 Q6ZPT5 Q9ESB6 Q9ESB8 A2AUM3 Q8CIF5 Q6GQT4 Q8C5S0 Q9CT30 Q9CUV9 Q9ESB7 (UniProt | EBI)

Last sequence update: 2005-03-15
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=eIF-2-alpha kinase GCN2 {ECO:0000305};AltName: Full=Eukaryotic translation initiation factor 2-alpha kinase 4 {ECO:0000312|MGI:MGI:1353427}; EC=2.7.11.1 {ECO:0000269|PubMed:10504407, ECO:0000269|PubMed:10655230, ECO:0000269|PubMed:16

Provider

SWISS-PROT

Sequence

Polypeptide 1648 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Eif2ak4	eukaryotic translation initiation factor 2 alpha kinase 4	82	109	3	14

Sequence references in MGI

J:58015 Berlanga JJ, et al., Characterization of a mammalian homolog of the GCN2 eukaryotic initiation factor 2alpha kinase. Eur J Biochem. 1999 Oct;265(2):754-62
J:71261 Sood R, et al., A mammalian homologue of GCN2 protein kinase important for translational control by phosphorylation of eukaryotic initiation factor-2alpha. Genetics. 2000 Feb;154(2):787-801
J:78945 Zhang P, et al., The GCN2 eIF2alpha kinase is required for adaptation to amino acid deprivation in mice. Mol Cell Biol. 2002 Oct;22(19):6681-8
J:86686 Okazaki N, et al., Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. DNA Res. 2003 Aug 31;10(4):167-80
J:92545 Anthony TG, et al., Preservation of liver protein synthesis during dietary leucine deprivation occurs at the expense of skeletal muscle mass in mice deleted for eIF2 kinase GCN2. J Biol Chem. 2004 Aug 27;279(35):36553-61
J:99455 Harding HP, et al., Regulated translation initiation controls stress-induced gene expression in mammalian cells. Mol Cell. 2000 Nov;6(5):1099-108
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:100646 Costa-Mattioli M, et al., Translational control of hippocampal synaptic plasticity and memory by the eIF2alpha kinase GCN2. Nature. 2005 Aug 25;436(7054):1166-73
J:107108 Hamanaka RB, et al., PERK and GCN2 contribute to eIF2alpha phosphorylation and cell cycle arrest after activation of the unfolded protein response pathway. Mol Biol Cell. 2005 Dec;16(12):5493-501
J:129841 Maurin AC, et al., The GCN2 kinase biases feeding behavior to maintain amino acid homeostasis in omnivores. Cell Metab. 2005 Apr;1(4):273-7
J:182847 Muaddi H, et al., Phosphorylation of eIF2alpha at serine 51 is an important determinant of cell survival and adaptation to glucose deficiency. Mol Biol Cell. 2010 Sep 15;21(18):3220-31
J:197824 Roffe M, et al., IMPACT is a developmentally regulated protein in neurons that opposes the eukaryotic initiation factor 2alpha kinase GCN2 in the modulation of neurite outgrowth. J Biol Chem. 2013 Apr 12;288(15):10860-9
J:205264 Ravindran R, et al., Vaccine activation of the nutrient sensor GCN2 in dendritic cells enhances antigen presentation. Science. 2014 Jan 17;343(6168):313-7
J:211861 Cambiaghi TD, et al., Evolutionarily conserved IMPACT impairs various stress responses that require GCN1 for activating the eIF2 kinase GCN2. Biochem Biophys Res Commun. 2014 Jan 10;443(2):592-7
J:218404 Roobol A, et al., p58IPK is an inhibitor of the eIF2alpha kinase GCN2 and its localization and expression underpin protein synthesis and ER processing capacity. Biochem J. 2015 Jan 15;465(2):213-25
J:227362 Lehman SL, et al., Translational Upregulation of an Individual p21Cip1 Transcript Variant by GCN2 Regulates Cell Proliferation and Survival under Nutrient Stress. PLoS Genet. 2015 Jun;11(6):e1005212
J:227388 Berlanga JJ, et al., Antiviral effect of the mammalian translation initiation factor 2alpha kinase GCN2 against RNA viruses. EMBO J. 2006 Apr 19;25(8):1730-40
J:227395 Deng J, et al., Activation of GCN2 in UV-irradiated cells inhibits translation. Curr Biol. 2002 Aug 6;12(15):1279-86
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89