Sequence Detail

ID/Version

Q9QYY8 Q80VE0 Q9CVK0 Q6ZPY6 (UniProt | EBI)

Last sequence update: 2009-03-24
Last annotation update: 2024-01-24

Sequence description from provider

RecName: Full=Spastin {ECO:0000255|HAMAP-Rule:MF_03021}; EC=5.6.1.1 {ECO:0000255|HAMAP-Rule:MF_03021};

Provider

SWISS-PROT

Sequence

Polypeptide 614 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Spast	spastin	84	100	3	24

Sequence references in MGI

J:61872 Hazan J, et al., Spastin, a new AAA protein, is altered in the most frequent form of autosomal dominant spastic paraplegia. Nat Genet. 1999 Nov;23(3):296-303
J:86686 Okazaki N, et al., Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. DNA Res. 2003 Aug 31;10(4):167-80
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:102809 Claudiani P, et al., Spastin subcellular localization is regulated through usage of different translation start sites and active export from the nucleus. Exp Cell Res. 2005 Oct 1;309(2):358-69
J:117740 Tarrade A, et al., A mutation of spastin is responsible for swellings and impairment of transport in a region of axon characterized by changes in microtubule composition. Hum Mol Genet. 2006 Dec 15;15(24):3544-58
J:146167 Riano E, et al., Pleiotropic effects of spastin on neurite growth depending on expression levels. J Neurochem. 2009 Mar;108(5):1277-88
J:148877 Kasher PR, et al., Direct evidence for axonal transport defects in a novel mouse model of mutant spastin-induced hereditary spastic paraplegia (HSP) and human HSP patients. J Neurochem. 2009 Jul;110(1):34-44
J:162689 Lacroix B, et al., Tubulin polyglutamylation stimulates spastin-mediated microtubule severing. J Cell Biol. 2010 Jun 14;189(6):945-54
J:192671 Fassier C, et al., Microtubule-targeting drugs rescue axonal swellings in cortical neurons from spastin knockout mice. Dis Model Mech. 2013 Jan;6(1):72-83
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89