Sequence Detail

ID/Version

Q9QYX7 E9QK94 Q9QYX6 Q8CF92 Q9QZJ0 Q8CF91 (UniProt | EBI)

Last sequence update: 2013-01-09
Last annotation update: 2025-06-18

Sequence description from provider

RecName: Full=Protein piccolo {ECO:0000305};AltName: Full=Aczonin {ECO:0000303|PubMed:10508862};AltName: Full=Brain-derived HLMN protein;AltName: Full=Multidomain presynaptic cytomatrix protein;

Provider

SWISS-PROT

Sequence

Polypeptide 5068 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Pclo	piccolo (presynaptic cytomatrix protein)	74	102	4	11

Sequence references in MGI

J:57915 Wang X, et al., Aczonin, a 550-kD putative scaffolding protein of presynaptic active zones, shares homology regions with Rim and Bassoon and binds profilin. J Cell Biol. 1999 Oct 4;147(1):151-62
J:81000 Fujimoto K, et al., Piccolo, a Ca2+ sensor in pancreatic beta-cells. Involvement of cAMP-GEFII.Rim2.Piccolo complex in cAMP-dependent exocytosis. J Biol Chem. 2002 Dec 27;277(52):50497-502
J:153882 Wang X, et al., A protein interaction node at the neurotransmitter release site: domains of Aczonin/Piccolo, Bassoon, CAST, and rim converge on the N-terminal domain of Munc13-1. J Neurosci. 2009 Oct 7;29(40):12584-96
J:187362 Munton RP, et al., Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations. Mol Cell Proteomics. 2007 Feb;6(2):283-93
J:256127 Okerlund ND, et al., Bassoon Controls Presynaptic Autophagy through Atg5. Neuron. 2017 Feb 22;93(4):897-913.e7
J:263376 Trinidad JC, et al., Comprehensive identification of phosphorylation sites in postsynaptic density preparations. Mol Cell Proteomics. 2006 May;5(5):914-22
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89