Sequence Detail

ID/Version

Q9QY96 Q9R1Y2 G3UX06 Q9QZU8 O08968 Q9QY95 O88519 Q9R1D6 (UniProt | EBI)

Last sequence update: 2012-10-03
Last annotation update: 2025-06-18

Sequence description from provider

RecName: Full=Extracellular calcium-sensing receptor {ECO:0000303|PubMed:15347804}; Short=CaSR {ECO:0000303|PubMed:15347804};AltName: Full=Parathyroid cell calcium-sensing receptor; Short=PCaR1;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 1079 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Casr	calcium-sensing receptor	124	110	3	23

Sequence references in MGI

J:29900 Ho C, et al., A mouse model of human familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism [see comments]. Nat Genet. 1995 Dec;11(4):389-94
J:59382 Oda Y, et al., The calcium sensing receptor and its alternatively spliced form in murine epidermal differentiation. J Biol Chem. 2000 Jan 14;275(2):1183-90
J:75200 Chang W, et al., Expression and signal transduction of calcium-sensing receptors in cartilage and bone. Endocrinology. 1999 Dec;140(12):5883-93
J:75201 Pi M, et al., Sensing of extracellular cations in CasR-deficient osteoblasts. Evidence for a novel cation-sensing mechanism. J Biol Chem. 2000 Feb 4;275(5):3256-63
J:75202 Quarles LD, et al., A distinct cation-sensing mechanism in MC3T3-E1 osteoblasts functionally related to the calcium receptor. J Bone Miner Res. 1997 Mar;12(3):393-402
J:82624 Kos CH, et al., The calcium-sensing receptor is required for normal calcium homeostasis independent of parathyroid hormone. J Clin Invest. 2003 Apr;111(7):1021-8
J:92612 Hough TA, et al., Activating calcium-sensing receptor mutation in the mouse is associated with cataracts and ectopic calcification. Proc Natl Acad Sci U S A. 2004 Sep 14;101(37):13566-71
J:192821 Lee GS, et al., The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP. Nature. 2012 Dec 6;492(7427):123-7
J:226642 Wei WC, et al., Reciprocal regulation of two G protein-coupled receptors sensing extracellular concentrations of Ca2+ and H. Proc Natl Acad Sci U S A. 2015 Aug 25;112(34):10738-43
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89