Sequence Detail

ID/Version

Q9QXZ7 (UniProt | EBI)

Last sequence update: 2000-05-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Photoreceptor-specific nuclear receptor;AltName: Full=Nuclear receptor subfamily 2 group E member 3;AltName: Full=Retina-specific nuclear receptor;

Provider

SWISS-PROT

Sequence

Polypeptide 395 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Nr2e3	nuclear receptor subfamily 2, group E, member 3	35	130	3	7

Sequence references in MGI

J:59079 Chen F, et al., Retina-specific nuclear receptor: A potential regulator of cellular retinaldehyde-binding protein expressed in retinal pigment epithelium and Muller glial cells. Proc Natl Acad Sci U S A. 1999 Dec 21;96(26):15149-54
J:62171 Akhmedov NB, et al., A deletion in a photoreceptor-specific nuclear receptor mRNA causes retinal degeneration in the rd7 mouse. Proc Natl Acad Sci U S A. 2000 May 9;97(10):5551-6
J:91665 Cheng H, et al., Photoreceptor-specific nuclear receptor NR2E3 functions as a transcriptional activator in rod photoreceptors. Hum Mol Genet. 2004 Aug 1;13(15):1563-75
J:97032 Chen J, et al., The rod photoreceptor-specific nuclear receptor Nr2e3 represses transcription of multiple cone-specific genes. J Neurosci. 2005 Jan 5;25(1):118-29
J:147163 Onishi A, et al., Pias3-dependent SUMOylation directs rod photoreceptor development. Neuron. 2009 Jan 29;61(2):234-46
J:171710 Mollema NJ, et al., Nuclear receptor Rev-erb alpha (Nr1d1) functions in concert with Nr2e3 to regulate transcriptional networks in the retina. PLoS One. 2011;6(3):e17494
J:253631 Omori Y, et al., Samd7 is a cell type-specific PRC1 component essential for establishing retinal rod photoreceptor identity. Proc Natl Acad Sci U S A. 2017 Sep 26;114(39):E8264-E8273