Sequence Detail

ID/Version

Q9QXZ0 P97396 Q4PLL5 P97395 B1ARU3 P97394 (UniProt | EBI)

Last sequence update: 2011-06-28
Last annotation update: 2025-06-18

Sequence description from provider

RecName: Full=Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4 {ECO:0000305};AltName: Full=Actin cross-linking family 7;

Provider

SWISS-PROT

Sequence

Polypeptide 7354 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Macf1	microtubule-actin crosslinking factor 1	98	117	3	545

Sequence references in MGI

J:36985 Bernier G, et al., Cloning and characterization of mouse ACF7, a novel member of the dystonin subfamily of actin binding proteins. Genomics. 1996 Nov 15;38(1):19-29
J:58933 Leung CL, et al., Microtubule actin cross-linking factor (MACF): a hybrid of dystonin and dystrophin that can interact with the actin and microtubule cytoskeletons. J Cell Biol. 1999 Dec 13;147(6):1275-86
J:101503 Lin CM, et al., Microtubule actin crosslinking factor 1b: a novel plakin that localizes to the Golgi complex. J Cell Sci. 2005 Aug 15;118(Pt 16):3727-38
J:110693 Chen HJ, et al., The role of microtubule actin cross-linking factor 1 (MACF1) in the Wnt signaling pathway. Genes Dev. 2006 Jul 15;20(14):1933-45
J:143595 Wu X, et al., ACF7 regulates cytoskeletal-focal adhesion dynamics and migration and has ATPase activity. Cell. 2008 Oct 3;135(1):137-48
J:170927 Wu X, et al., Skin stem cells orchestrate directional migration by regulating microtubule-ACF7 connections through GSK3beta. Cell. 2011 Feb 4;144(3):341-52
J:187362 Munton RP, et al., Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations. Mol Cell Proteomics. 2007 Feb;6(2):283-93
J:263376 Trinidad JC, et al., Comprehensive identification of phosphorylation sites in postsynaptic density preparations. Mol Cell Proteomics. 2006 May;5(5):914-22
J:276410 Ka M, et al., Microtubule-Actin Crosslinking Factor 1 Is Required for Dendritic Arborization and Axon Outgrowth in the Developing Brain. Mol Neurobiol. 2016 Nov;53(9):6018-6032
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89