Sequence Detail

ID/Version

Q9QXV9 (UniProt | EBI)

Last sequence update: 2000-05-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Protein sprouty homolog 1; Short=Spry-1;

Provider

SWISS-PROT

Sequence

Polypeptide 313 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Spry1	sprouty RTK signaling antagonist 1	55	135	3	14

Sequence references in MGI

J:55241 Minowada G, et al., Vertebrate Sprouty genes are induced by FGF signaling and can cause chondrodysplasia when overexpressed. Development. 1999 Oct;126(20):4465-75
J:116930 Cabrita MA, et al., A functional interaction between sprouty proteins and caveolin-1. J Biol Chem. 2006 Sep 29;281(39):29201-2912
J:130605 Chandramouli S, et al., Tesk1 interacts with Spry2 to abrogate its inhibition of ERK phosphorylation downstream of receptor tyrosine kinase signaling. J Biol Chem. 2008 Jan 18;283(3):1679-91
J:287032 Zhao G, et al., Negative regulation of TGFbeta-induced lens epithelial to mesenchymal transition (EMT) by RTK antagonists. Exp Eye Res. 2015 Mar;132:9-16
J:287039 Zhao G, et al., Negative regulation of lens fiber cell differentiation by RTK antagonists Spry and Spred. Exp Eye Res. 2018 May;170:148-159