Sequence Detail

ID/Version

Q9QXJ1 E9QNW5 O08642 Q8BNF4 Q8BSR9 Q3TPU0 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=Amyloid beta precursor protein binding family B member 1 {ECO:0000250|UniProtKB:O00213};AltName: Full=Amyloid-beta A4 precursor protein-binding family B member 1 {ECO:0000312|MGI:MGI:107765};AltName: Full=Protein Fe65 {ECO:0000303|PubMed:940

Provider

SWISS-PROT

Sequence

Polypeptide 710 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Apbb1	amyloid beta precursor protein binding family B member 1	88	106	3	11

Sequence references in MGI

J:35780 Bressler SL, et al., cDNA cloning and chromosome mapping of the human Fe65 gene: interaction of the conserved cytoplasmic domains of the human beta-amyloid precursor protein and its homologues with the mouse Fe65 protein. Hum Mol Genet. 1996 Oct;5(10):1589-98
J:44866 Ermekova KS, et al., The WW domain of neural protein FE65 interacts with proline-rich motifs in Mena, the mammalian homolog of Drosophila enabled. J Biol Chem. 1997 Dec 26;272(52):32869-77
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:118164 Minopoli G, et al., Essential roles for Fe65, Alzheimer amyloid precursor-binding protein, in the cellular response to DNA damage. J Biol Chem. 2007 Jan 12;282(2):831-5
J:164771 Kajiwara Y, et al., FE65 binds Teashirt, inhibiting expression of the primate-specific caspase-4. PLoS One. 2009;4(4):e5071
J:223355 Suh J, et al., FE65 and FE65L1 amyloid precursor protein-binding protein compound null mice display adult-onset cataract and muscle weakness. FASEB J. 2015 Jun;29(6):2628-39
J:238186 Matz A, et al., Regulation of neuronal survival and morphology by the E3 ubiquitin ligase RNF157. Cell Death Differ. 2015 Apr;22(4):626-42
J:263434 Strecker P, et al., FE65 and FE65L1 share common synaptic functions and genetically interact with the APP family in neuromuscular junction formation. Sci Rep. 2016 May 11;6:25652
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89