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Sequence Detail
Q9QX98 Q9QYF6 Q9QYF5 (UniProt | EBI) Last sequence update: 2000-05-01
Last annotation update: 2019-09-18
from provider
RecName: Full=Pancreas transcription factor 1 subunit alpha;AltName: Full=Pancreas-specific transcription factor 1a;AltName: Full=bHLH transcription factor p48;AltName: Full=p48 DNA-binding subunit of transcription factor PTF1; Short=PTF1-p48;
Polypeptide 324 aa
For this sequence
Organism mouse
See UniProt | EBI for source
Annotated genes and markers Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.
Type Symbol Name GO Terms Expression
Orthologs Phenotypic
Gene Ptf1a pancreas specific transcription factor, 1a 43 33 7 20
Sequence references in MGI J:51571 Krapp A, et al., The bHLH protein PTF1-p48 is essential for the formation of the exocrine and the correct spatial organization of the endocrine pancreas. Genes Dev. 1998 Dec 1;12(23):3752-63
J:62777 Obata J, et al., p48 subunit of mouse PTF1 binds to RBP-Jkappa/CBF-1, the intracellular mediator of Notch signalling, and is expressed in the neural tube of early stage embryos. Genes Cells. 2001 Apr;6(4):345-60
J:72789 Rose SD, et al., The Role of PTF1-P48 in Pancreatic Acinar Gene Expression. J Biol Chem. 2001 Nov 23;276(47):44018-26
J:78710 Kawaguchi Y, et al., The role of the transcriptional regulator Ptf1a in converting intestinal to pancreatic progenitors. Nat Genet. 2002 Sep;32(1):128-34
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:115271 Fujitani Y, et al., Ptf1a determines horizontal and amacrine cell fates during mouse retinal development. Development. 2006 Nov;133(22):4439-50
J:120017 Sellick GS, et al., Mutations in PTF1A cause pancreatic and cerebellar agenesis. Nat Genet. 2004 Dec;36(12):1301-5

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory