Sequence Detail

ID/Version

Q9QX98 Q9QYF5 Q9QYF6 (UniProt | EBI)

Last sequence update: 2000-05-01
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=Pancreas transcription factor 1 subunit alpha;AltName: Full=Pancreas-specific transcription factor 1a;AltName: Full=bHLH transcription factor p48;AltName: Full=p48 DNA-binding subunit of transcription factor PTF1; Short=PTF1-p48;

Provider

SWISS-PROT

Sequence

Polypeptide 324 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Ptf1a	pancreas specific transcription factor, 1a	56	141	3	25

Sequence references in MGI

J:51571 Krapp A, et al., The bHLH protein PTF1-p48 is essential for the formation of the exocrine and the correct spatial organization of the endocrine pancreas. Genes Dev. 1998 Dec 1;12(23):3752-63
J:62777 Obata J, et al., p48 subunit of mouse PTF1 binds to RBP-Jkappa/CBF-1, the intracellular mediator of Notch signalling, and is expressed in the neural tube of early stage embryos. Genes Cells. 2001 Apr;6(4):345-60
J:72789 Rose SD, et al., The Role of PTF1-P48 in Pancreatic Acinar Gene Expression. J Biol Chem. 2001 Nov 23;276(47):44018-26
J:78710 Kawaguchi Y, et al., The role of the transcriptional regulator Ptf1a in converting intestinal to pancreatic progenitors. Nat Genet. 2002 Sep;32(1):128-34
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:115271 Fujitani Y, et al., Ptf1a determines horizontal and amacrine cell fates during mouse retinal development. Development. 2006 Nov;133(22):4439-50
J:120017 Sellick GS, et al., Mutations in PTF1A cause pancreatic and cerebellar agenesis. Nat Genet. 2004 Dec;36(12):1301-5
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89