Sequence Detail

ID/Version

Q9QWL7 A2A4G6 Q61783 (UniProt | EBI)

Last sequence update: 2007-01-23
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Keratin, type I cytoskeletal 17;AltName: Full=Cytokeratin-17; Short=CK-17;AltName: Full=Keratin-17; Short=K17;

Provider

SWISS-PROT

Sequence

Polypeptide 433 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Krt17	keratin 17	28	115	12	19

Sequence references in MGI

J:30054 Knapp B, et al., Three cDNA sequences of mouse type I keratins. Cellular localization of the mRNAs in normal and hyperproliferative tissues. J Biol Chem. 1987 Jan 15;262(2):938-45
J:50471 McGowan KM, et al., Onset of keratin 17 expression coincides with the definition of major epithelial lineages during skin development. J Cell Biol. 1998 Oct 19;143(2):469-86
J:54007 Sato H, et al., The genomic organization of type I keratin genes in mice. Genomics. 1999 Mar 15;56(3):303-9
J:62819 McGowan KM, et al., Keratin 17 expression in the hard epithelial context of the hair and nail, and its relevance for the pachyonychia congenita phenotype. J Invest Dermatol. 2000 Jun;114(6):1101-7
J:76311 Peters B, et al., Complete cytolysis and neonatal lethality in keratin 5 knockout mice reveal its fundamental role in skin integrity and in epidermolysis bullosa simplex. Mol Biol Cell. 2001 Jun;12(6):1775-89
J:82089 McGowan KM, et al., Keratin 17 null mice exhibit age- and strain-dependent alopecia. Genes Dev. 2002 Jun 1;16(11):1412-22
J:108710 Tong X, et al., Keratin 17 modulates hair follicle cycling in a TNFalpha-dependent fashion. Genes Dev. 2006 May 15;20(10):1353-64
J:109025 Kim S, et al., A keratin cytoskeletal protein regulates protein synthesis and epithelial cell growth. Nature. 2006 May 18;441(7091):362-5
J:165573 Depianto D, et al., Keratin 17 promotes epithelial proliferation and tumor growth by polarizing the immune response in skin. Nat Genet. 2010 Oct;42(10):910-4
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89