Sequence Detail

ID/Version

Q9QWK4 O35300 Q3TXN5 Q91W05 O35301 Q505P6 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=CD5 antigen-like;AltName: Full=Apoptosis inhibitor expressed by macrophages {ECO:0000303|PubMed:9892623}; Short=mAIM {ECO:0000303|PubMed:23236605};AltName: Full=Apoptosis inhibitory 6;AltName: Full=SP-alpha {ECO:0000303|PubMed:106519

Provider

SWISS-PROT

Sequence

Polypeptide 352 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Cd5l	CD5 antigen-like	13	103	2	13

Sequence references in MGI

J:52195 Miyazaki T, et al., Increased susceptibility of thymocytes to apoptosis in mice lacking AIM, a novel murine macrophage-derived soluble factor belonging to the scavenger receptor cysteine-rich domain superfamily. J Exp Med. 1999 Jan 18;189(2):413-22
J:59435 Gebe JA, et al., Molecular cloning, genomic organization and cell-binding characteristics of mouse Spalpha. Immunology. 2000 Jan;99(1):78-86
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:129845 Arai S, et al., A role for the apoptosis inhibitory factor AIM/Spalpha/Api6 in atherosclerosis development. Cell Metab. 2005 Mar;1(3):201-13
J:160912 Kurokawa J, et al., Macrophage-derived AIM is endocytosed into adipocytes and decreases lipid droplets via inhibition of fatty acid synthase activity. Cell Metab. 2010 Jun 9;11(6):479-92
J:174367 Kurokawa J, et al., Apoptosis inhibitor of macrophage (AIM) is required for obesity-associated recruitment of inflammatory macrophages into adipose tissue. Proc Natl Acad Sci U S A. 2011 Jul 19;108(29):12072-7
J:197958 Mori M, et al., Modification of N-glycosylation modulates the secretion and lipolytic function of apoptosis inhibitor of macrophage (AIM). FEBS Lett. 2012 Oct 19;586(20):3569-74
J:198540 Arai S, et al., Obesity-associated autoantibody production requires AIM to retain the immunoglobulin M immune complex on follicular dendritic cells. Cell Rep. 2013 Apr 25;3(4):1187-98
J:228004 Gaublomme JT, et al., Single-Cell Genomics Unveils Critical Regulators of Th17 Cell Pathogenicity. Cell. 2015 Dec 3;163(6):1400-12
J:228005 Wang C, et al., CD5L/AIM Regulates Lipid Biosynthesis and Restrains Th17 Cell Pathogenicity. Cell. 2015 Dec 3;163(6):1413-27