Sequence Detail

ID/Version

Q9QVP9 G3X8V1 B2RQ16 (UniProt | EBI)

Last sequence update: 2012-10-03
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Protein-tyrosine kinase 2-beta; EC=2.7.10.2;AltName: Full=Calcium-dependent tyrosine kinase; Short=CADTK;AltName: Full=Calcium-regulated non-receptor proline-rich tyrosine kinase;AltName: Full=Cell adhesion kinase beta;

Provider

SWISS-PROT

Sequence

Polypeptide 1009 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Ptk2b	PTK2 protein tyrosine kinase 2 beta	225	108	4	23

Sequence references in MGI

J:29773 Avraham S, et al., Identification and characterization of a novel related adhesion focal tyrosine kinase (RAFTK) from megakaryocytes and brain. J Biol Chem. 1995 Nov 17;270(46):27742-51
J:45163 Matsuya M, et al., Cell adhesion kinase beta forms a complex with a new member, Hic-5, of proteins localized at focal adhesions. J Biol Chem. 1998 Jan 9;273(2):1003-14
J:63286 Guinamard R, et al., Absence of marginal zone B cells in Pyk-2-deficient mice defines their role in the humoral response. Nat Immunol. 2000 Jul;1(1):31-6
J:67886 Ren XR, et al., Regulation of CDC42 GTPase by Proline-rich Tyrosine Kinase 2 Interacting with PSGAP, a Novel Pleckstrin Homology and Src Homology 3 Domain Containing rhoGAP Protein. J Cell Biol. 2001 Mar 5;152(5):971-84
J:89495 Miyazaki T, et al., Src kinase activity is essential for osteoclast function. J Biol Chem. 2004 Apr 23;279(17):17660-6
J:94595 Continolo S, et al., The proto-oncogene Fgr regulates cell migration and this requires its plasma membrane localization. Exp Cell Res. 2005 Jan 15;302(2):253-69
J:99741 Okigaki M, et al., Pyk2 regulates multiple signaling events crucial for macrophage morphology and migration. Proc Natl Acad Sci U S A. 2003 Sep 16;100(19):10740-5
J:122285 Buckbinder L, et al., Proline-rich tyrosine kinase 2 regulates osteoprogenitor cells and bone formation, and offers an anabolic treatment approach for osteoporosis. Proc Natl Acad Sci U S A. 2007 Jun 19;104(25):10619-24
J:134795 Gil-Henn H, et al., Defective microtubule-dependent podosome organization in osteoclasts leads to increased bone density in Pyk2(-/-) mice. J Cell Biol. 2007 Sep 10;178(6):1053-64
J:137848 Xu J, et al., Nonmuscle myosin light-chain kinase mediates neutrophil transmigration in sepsis-induced lung inflammation by activating beta2 integrins. Nat Immunol. 2008 Aug;9(8):880-6
J:139849 Matsui A, et al., Central role of calcium-dependent tyrosine kinase PYK2 in endothelial nitric oxide synthase-mediated angiogenic response and vascular function. Circulation. 2007 Aug 28;116(9):1041-51
J:143718 Trost M, et al., The phagosomal proteome in interferon-gamma-activated macrophages. Immunity. 2009 Jan;30(1):143-54
J:159965 Lim ST, et al., Pyk2 inhibition of p53 as an adaptive and intrinsic mechanism facilitating cell proliferation and survival. J Biol Chem. 2010 Jan 15;285(3):1743-53
J:174314 Shen CJ, et al., Decreased cell adhesion promotes angiogenesis in a Pyk2-dependent manner. Exp Cell Res. 2011 Aug 1;317(13):1860-71
J:180487 Gupta A, et al., Leupaxin is a critical adaptor protein in the adhesion zone of the osteoclast. J Bone Miner Res. 2003 Apr;18(4):669-85
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89