Sequence Detail

ID/Version

Q9QUG3 Q9QZT5 (UniProt | EBI)

Last sequence update: 2000-05-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Prion-like protein doppel;AltName: Full=Doppelganger; Short=Dpl {ECO:0000303|PubMed:12110578};AltName: Full=PrPLP;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 179 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Prnd	prion like protein doppel	21	108	2	10

Sequence references in MGI

J:42407 Moore RC, et al., Ataxia in prion protein (PrP)-deficient mice is associated with upregulation of the novel PrP-like protein doppel. J Mol Biol. 1999 Oct 1;292(4):797-817
J:64416 Silverman GL, et al., Doppel is an N-glycosylated, glycosylphosphatidylinositol-anchored protein. Expression in testis and ectopic production in the brains of Prnp(0/0) mice predisposed to Purkinje cell loss. J Biol Chem. 2000 Sep 1;275(35):26834-41
J:67978 Li A, et al., Identification of a novel gene encoding a PrP-like protein expressed as chimeric transcripts fused to PrP exon 1/2 in ataxic mouse line with a disrupted PrP gene. Cell Mol Neurobiol. 2000 Oct;20(5):553-67
J:89232 Genoud N, et al., Disruption of Doppel prevents neurodegeneration in mice with extensive Prnp deletions. Proc Natl Acad Sci U S A. 2004 Mar 23;101(12):4198-203
J:91094 Paisley D, et al., Male infertility and DNA damage in Doppel knockout and prion protein/Doppel double-knockout mice. Am J Pathol. 2004 Jun;164(6):2279-88
J:91621 Behrens A, et al., Absence of the prion protein homologue Doppel causes male sterility. EMBO J. 2002 Jul 15;21(14):3652-8