Sequence Detail

ID/Version

Q9JM73 (UniProt | EBI)

Last sequence update: 2000-10-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Serum response factor; Short=SRF;

Provider

SWISS-PROT

Sequence

Polypeptide 504 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Srf	serum response factor	184	131	4	21

Sequence references in MGI

J:91025 Parlakian A, et al., Targeted inactivation of serum response factor in the developing heart results in myocardial defects and embryonic lethality. Mol Cell Biol. 2004 Jun;24(12):5281-9
J:95039 Zhang X, et al., Identification of a novel serum response factor cofactor in cardiac gene regulation. J Biol Chem. 2004 Dec 31;279(53):55626-32
J:110513 Zhang X, et al., Zipzap/p200 is a novel zinc finger protein contributing to cardiac gene regulation. Biochem Biophys Res Commun. 2006 Aug 4;346(3):794-801
J:113460 Kim MS, et al., Co-activation of atrial natriuretic factor promoter by Tip60 and serum response factor. J Biol Chem. 2006 Jun 2;281(22):15082-9
J:114835 Ju JH, et al., Physical and functional interactions between the prostate suppressor homeoprotein NKX3.1 and serum response factor. J Mol Biol. 2006 Jul 28;360(5):989-99
J:150313 Brandt DT, et al., SCAI acts as a suppressor of cancer cell invasion through the transcriptional control of beta1-integrin. Nat Cell Biol. 2009 May;11(5):557-68
J:265605 Esnault C, et al., Rho-actin signaling to the MRTF coactivators dominates the immediate transcriptional response to serum in fibroblasts. Genes Dev. 2014 May 1;28(9):943-58
J:265732 Miralles F, et al., Actin dynamics control SRF activity by regulation of its coactivator MAL. Cell. 2003 May 2;113(3):329-42
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:343405 Ferris LA, et al., Purine-rich element binding protein B attenuates the coactivator function of myocardin by a novel molecular mechanism of smooth muscle gene repression. Mol Cell Biochem. 2021 Aug;476(8):2899-2916