Sequence Detail

ID/Version

Q9JLZ8 Q52L48 (UniProt | EBI)

Last sequence update: 2005-09-27
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Single Ig IL-1-related receptor;AltName: Full=Single Ig IL-1R-related molecule;AltName: Full=Single immunoglobulin domain-containing IL1R-related protein;AltName: Full=Toll/interleukin-1 receptor 8; Short=TIR8;

Provider

SWISS-PROT

Sequence

Polypeptide 409 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Sigirr	single immunoglobulin and toll-interleukin 1 receptor (TIR) domain	16	98	3	21

Sequence references in MGI

J:55824 Thomassen E, et al., Identification and characterization of SIGIRR, a molecule representing a novel subtype of the IL-1R superfamily. Cytokine. 1999 Jun;11(6):389-99
J:85151 Wald D, et al., SIGIRR, a negative regulator of Toll-like receptor-interleukin 1 receptor signaling. Nat Immunol. 2003 Sep;4(9):920-7
J:88907 Garlanda C, et al., Intestinal inflammation in mice deficient in Tir8, an inhibitory member of the IL-1 receptor family. Proc Natl Acad Sci U S A. 2004 Mar 9;101(10):3522-6
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89