Sequence Detail

ID/Version

Q9JLN9 Q811J5 Q9CST1 Q2KHT0 (UniProt | EBI)

Last sequence update: 2010-06-15
Last annotation update: 2025-06-18

Sequence description from provider

RecName: Full=Serine/threonine-protein kinase mTOR {ECO:0000305}; EC=2.7.11.1 {ECO:0000269|PubMed:11792863, ECO:0000269|PubMed:18566586, ECO:0000269|PubMed:18566587, ECO:0000269|PubMed:21321111, ECO:0000269|PubMed:27913603, ECO:0000269|PubMed:3154

Provider

SWISS-PROT

Sequence

Polypeptide 2549 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Mtor	mechanistic target of rapamycin kinase	353	135	3	43

Sequence references in MGI

J:93907 Jacinto E, et al., Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive. Nat Cell Biol. 2004 Nov;6(11):1122-8
J:94133 Gangloff YG, et al., Disruption of the mouse mTOR gene leads to early postimplantation lethality and prohibits embryonic stem cell development. Mol Cell Biol. 2004 Nov;24(21):9508-16
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:104099 Hresko RC, et al., mTOR.RICTOR is the Ser473 kinase for Akt/protein kinase B in 3T3-L1 adipocytes. J Biol Chem. 2005 Dec 9;280(49):40406-16
J:111744 Bernardi R, et al., PML inhibits HIF-1alpha translation and neoangiogenesis through repression of mTOR. Nature. 2006 Aug 17;442(7104):779-85
J:125618 Jacinto E, et al., SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity. Cell. 2006 Oct 6;127(1):125-37
J:128527 Cunningham JT, et al., mTOR controls mitochondrial oxidative function through a YY1-PGC-1alpha transcriptional complex. Nature. 2007 Nov 29;450(7170):736-40
J:137601 Ikenoue T, et al., Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling. EMBO J. 2008 Jul 23;27(14):1919-31
J:137614 Facchinetti V, et al., The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C. EMBO J. 2008 Jul 23;27(14):1932-43
J:150006 Smink JJ, et al., Transcription factor C/EBPbeta isoform ratio regulates osteoclastogenesis through MafB. EMBO J. 2009 Jun 17;28(12):1769-81
J:151331 Acosta-Jaquez HA, et al., Site-specific mTOR phosphorylation promotes mTORC1-mediated signaling and cell growth. Mol Cell Biol. 2009 Aug;29(15):4308-24
J:153992 Liu GH, et al., Regulation of myoblast differentiation by the nuclear envelope protein NET39. Mol Cell Biol. 2009 Nov;29(21):5800-12
J:164024 Takai H, et al., Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexes. Genes Dev. 2010 Sep 15;24(18):2019-30
J:167176 Oh WJ, et al., mTORC2 can associate with ribosomes to promote cotranslational phosphorylation and stability of nascent Akt polypeptide. EMBO J. 2010 Dec 1;29(23):3939-51
J:175316 Kim J, et al., AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1. Nat Cell Biol. 2011 Feb;13(2):132-41
J:193606 Dai N, et al., mTOR complex 2 phosphorylates IMP1 cotranslationally to promote IGF2 production and the proliferation of mouse embryonic fibroblasts. Genes Dev. 2013 Feb 1;27(3):301-12
J:193983 Kim SJ, et al., mTOR complex 2 regulates proper turnover of insulin receptor substrate-1 via the ubiquitin ligase subunit Fbw8. Mol Cell. 2012 Dec 28;48(6):875-87
J:207232 Seldin MM, et al., Skeletal muscle-derived myonectin activates the mammalian target of rapamycin (mTOR) pathway to suppress autophagy in liver. J Biol Chem. 2013 Dec 13;288(50):36073-82
J:210466 Liu P, et al., Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus. Nature. 2014 Apr 24;508(7497):541-5
J:215861 Meffre J, et al., 5-HT(6) receptor recruitment of mTOR as a mechanism for perturbed cognition in schizophrenia. EMBO Mol Med. 2012 Oct;4(10):1043-56
J:243471 Cattin ME, et al., Deletion of MLIP (muscle-enriched A-type lamin-interacting protein) leads to cardiac hyperactivation of Akt/mammalian target of rapamycin (mTOR) and impaired cardiac adaptation. J Biol Chem. 2015 Oct 30;290(44):26699-714
J:252270 Guri Y, et al., mTORC2 Promotes Tumorigenesis via Lipid Synthesis. Cancer Cell. 2017 Dec 11;32(6):807-823.e12
J:257513 Bodur C, et al., The IKK-related kinase TBK1 activates mTORC1 directly in response to growth factors and innate immune agonists. EMBO J. 2018 Jan 4;37(1):19-38
J:263234 Ramanathan C, et al., mTOR signaling regulates central and peripheral circadian clock function. PLoS Genet. 2018 May;14(5):e1007369
J:282915 Kearney AL, et al., Serine 474 phosphorylation is essential for maximal Akt2 kinase activity in adipocytes. J Biol Chem. 2019 Nov 8;294(45):16729-16739
J:285017 Wada S, et al., The tumor suppressor FLCN mediates an alternate mTOR pathway to regulate browning of adipose tissue. Genes Dev. 2016 Nov 15;30(22):2551-2564
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:316837 Evavold CL, et al., Control of gasdermin D oligomerization and pyroptosis by the Ragulator-Rag-mTORC1 pathway. Cell. 2021 Aug 19;184(17):4495-4511.e19
J:328512 Tooley AS, et al., The innate immune kinase TBK1 directly increases mTORC2 activity and downstream signaling to Akt. J Biol Chem. 2021 Jul 8;297(2):100942
J:355636 Baffi TR, et al., mTORC2 controls the activity of PKC and Akt by phosphorylating a conserved TOR interaction motif. Sci Signal. 2021 Apr 13;14(678)
J:355659 Wu YT, et al., mTOR complex 2 targets Akt for proteasomal degradation via phosphorylation at the hydrophobic motif. J Biol Chem. 2011 Apr 22;286(16):14190-8