Sequence Detail

ID/Version

Q9JLB2 (UniProt | EBI)

Last sequence update: 2000-10-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Protein PALS1 {ECO:0000305};AltName: Full=MAGUK p55 subfamily member 5;AltName: Full=Protein associated with Lin-7 1 {ECO:0000303|PubMed:10753959, ECO:0000303|PubMed:11927608};

Provider

SWISS-PROT

Sequence

Polypeptide 675 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Pals1	protein associated with LIN7 1, MAGUK family member	69	110	4	14

Sequence references in MGI

J:64820 Kamberov E, et al., Molecular cloning and characterization of Pals, proteins associated with mLin-7. J Biol Chem. 2000 Apr 14;275(15):11425-31
J:91892 McHugh EM, et al., The GABA transporter GAT1 and the MAGUK protein Pals1: interaction, uptake modulation, and coexpression in the brain. Mol Cell Neurosci. 2004 Jul;26(3):406-17
J:92068 Van De Pavert SA, et al., Crumbs homologue 1 is required for maintenance of photoreceptor cell polarization and adhesion during light exposure. J Cell Sci. 2004 Aug 15;117(Pt 18):4169-77
J:159103 Ozcelik M, et al., Pals1 is a major regulator of the epithelial-like polarization and the extension of the myelin sheath in peripheral nerves. J Neurosci. 2010 Mar 17;30(11):4120-31
J:160624 Kim S, et al., The apical complex couples cell fate and cell survival to cerebral cortical development. Neuron. 2010 Apr 15;66(1):69-84
J:169049 Varelas X, et al., The Crumbs complex couples cell density sensing to Hippo-dependent control of the TGF-beta-SMAD pathway. Dev Cell. 2010 Dec 14;19(6):831-44
J:184469 Cho SH, et al., Genetic ablation of Pals1 in retinal progenitor cells models the retinal pathology of Leber congenital amaurosis. Hum Mol Genet. 2012 Jun 15;21(12):2663-76
J:191149 Alves CH, et al., Loss of CRB2 in the mouse retina mimics human retinitis pigmentosa due to mutations in the CRB1 gene. Hum Mol Genet. 2013 Jan 1;22(1):35-50
J:199562 Dudok JJ, et al., MPP3 regulates levels of PALS1 and adhesion between photoreceptors and Muller cells. Glia. 2013 Oct;61(10):1629-44
J:240000 Park JY, et al., The apical complex protein Pals1 is required to maintain cerebellar progenitor cells in a proliferative state. Development. 2016 Jan 01;143(1):133-46
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:296096 Gosens I, et al., FERM protein EPB41L5 is a novel member of the mammalian CRB-MPP5 polarity complex. Exp Cell Res. 2007 Nov 15;313(19):3959-70
J:298908 Paniagua AE, et al., CRB2 completes a fully expressed Crumbs complex in the Retinal Pigment Epithelium. Sci Rep. 2015 Sep 25;5:14504
J:333179 Kantardzhieva A, et al., MPP3 is recruited to the MPP5 protein scaffold at the retinal outer limiting membrane. FEBS J. 2006 Mar;273(6):1152-65