Sequence Detail

ID/Version

Q9JL18 Q8C793 Q9R1P7 Q3TNS7 Q8C5E9 (UniProt | EBI)

Last sequence update: 2000-10-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Beta-secretase 2; EC=3.4.23.45 {ECO:0000269|PubMed:21907142};AltName: Full=Aspartyl protease 1; Short=ASP1; Short=Asp 1;AltName: Full=Beta-site amyloid precursor protein cleaving enzyme 2; Short=Beta-site APP

Provider

SWISS-PROT

Sequence

Polypeptide 514 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Bace2	beta-site APP-cleaving enzyme 2	19	106	3	20

Sequence references in MGI

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:176653 Esterhazy D, et al., Bace2 Is a beta Cell-Enriched Protease that Regulates Pancreatic beta Cell Function and Mass. Cell Metab. 2011 Sep 7;14(3):365-77
J:197977 Rochin L, et al., BACE2 processes PMEL to form the melanosome amyloid matrix in pigment cells. Proc Natl Acad Sci U S A. 2013 Jun 25;110(26):10658-63