Sequence Detail

ID/Version

Q9JKV2 Q8K138 (UniProt | EBI)

Last sequence update: 2004-06-07
Last annotation update: 2025-06-18

Sequence description from provider

RecName: Full=Serine/threonine-protein kinase ICK; EC=2.7.11.1 {ECO:0000269|PubMed:24797473};AltName: Full=Intestinal cell kinase; Short=mICK;AltName: Full=MAK-related kinase; Short=MRK;

Provider

SWISS-PROT

Sequence

Polypeptide 629 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Cilk1	ciliogenesis associated kinase 1	66	102	2	42

Sequence references in MGI

J:60781 Togawa K, et al., Intestinal cell kinase (ICK) localizes to the crypt region and requires a dual phosphorylation site found in map kinases. J Cell Physiol. 2000 Apr;183(1):129-39
J:211652 Moon H, et al., Intestinal cell kinase, a protein associated with endocrine-cerebro-osteodysplasia syndrome, is a key regulator of cilia length and Hedgehog signaling. Proc Natl Acad Sci U S A. 2014 Jun 10;111(23):8541-6
J:211665 Chaya T, et al., ICK is essential for cell type-specific ciliogenesis and the regulation of ciliary transport. EMBO J. 2014 Jun 2;33(11):1227-42
J:233668 Broekhuis JR, et al., Regulation of cilium length and intraflagellar transport by the RCK-kinases ICK and MOK in renal epithelial cells. PLoS One. 2014;9(9):e108470
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:309178 Bailey JN, et al., Variant Intestinal-Cell Kinase in Juvenile Myoclonic Epilepsy. N Engl J Med. 2018 Mar 15;378(11):1018-1028