Sequence Detail

ID/Version

Q9JKK8 Q3TBS8 Q3TZM6 Q3UT26 Q571L3 Q3TNX3 Q3V1V6 (UniProt | EBI)

Last sequence update: 2005-03-29
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Serine/threonine-protein kinase ATR; EC=2.7.11.1;AltName: Full=Ataxia telangiectasia and Rad3-related protein;

Provider

SWISS-PROT

Sequence

Polypeptide 2635 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Atr	ataxia telangiectasia and Rad3 related	85	114	3	22

Sequence references in MGI

J:35913 Keegan KS, et al., The Atr and Atm protein kinases associate with different sites along meiotically pairing chromosomes [see comments]. Genes Dev. 1996 Oct 1;10(19):2423-37
J:60768 Brown EJ, et al., ATR disruption leads to chromosomal fragmentation and early embryonic lethality. Genes Dev. 2000 Feb 15;14(4):397-402
J:61732 de Klein A, et al., Targeted disruption of the cell-cycle checkpoint gene ATR leads to early embryonic lethality in mice. Curr Biol. 2000 Apr 20;10(8):479-82
J:83042 Brown EJ, et al., Essential and dispensable roles of ATR in cell cycle arrest and genome maintenance. Genes Dev. 2003 Mar 1;17(5):615-28
J:92574 Okazaki N, et al., Prediction of the coding sequences of mouse homologues of FLJ genes: the complete nucleotide sequences of 110 mouse FLJ-homologous cDnas identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. DNA Res. 2004 Apr 30;11(2):127-35
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:164024 Takai H, et al., Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexes. Genes Dev. 2010 Sep 15;24(18):2019-30
J:183982 Wojtasz L, et al., Meiotic DNA double-strand breaks and chromosome asynapsis in mice are monitored by distinct HORMAD2-independent and -dependent mechanisms. Genes Dev. 2012 May 1;26(9):958-73
J:192634 Kogo H, et al., HORMAD2 is essential for synapsis surveillance during meiotic prophase via the recruitment of ATR activity. Genes Cells. 2012 Nov;17(11):897-912
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:296112 Zhao B, et al., Mouse embryonic stem cells have increased capacity for replication fork restart driven by the specific Filia-Floped protein complex. Cell Res. 2018 Jan;28(1):69-89