Sequence Detail

ID/Version

Q9JKD8 Q3U150 Q9R0A6 (UniProt | EBI)

Last sequence update: 2000-10-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=T-box transcription factor TBX21; Short=T-box protein 21;AltName: Full=T-cell-specific T-box transcription factor T-bet;AltName: Full=Transcription factor TBLYM;

Provider

SWISS-PROT

Sequence

Polypeptide 530 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Tbx21	T-box 21	20	107	3	26

Sequence references in MGI

J:61321 Szabo SJ, et al., A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell. 2000 Mar 17;100(6):655-69
J:66047 Zhang Wx, et al., Cloning and characterization of a new member of the T-Box gene family. Genomics. 2000 Nov 15;70(1):41-8
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:166998 Miller SA, et al., Jmjd3 and UTX play a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression. Mol Cell. 2010 Nov 24;40(4):594-605
J:167439 Lazarevic V, et al., T-bet represses T(H)17 differentiation by preventing Runx1-mediated activation of the gene encoding RORgammat. Nat Immunol. 2011 Jan;12(1):96-104
J:175086 Chen A, et al., c-Abl-Mediated Tyrosine Phosphorylation of the T-bet DNA-Binding Domain Regulates CD4+ T-Cell Differentiation and Allergic Lung Inflammation. Mol Cell Biol. 2011 Aug;31(16):3445-56
J:204781 Jang EJ, et al., Lysine 313 of T-box is crucial for modulation of protein stability, DNA binding, and threonine phosphorylation of T-bet. J Immunol. 2013 Jun 1;190(11):5764-70
J:238297 Hertweck A, et al., T-bet Activates Th1 Genes through Mediator and the Super Elongation Complex. Cell Rep. 2016 Jun 21;15(12):2756-70
J:245321 Hwang ES, et al., T helper cell fate specified by kinase-mediated interaction of T-bet with GATA-3. Science. 2005 Jan 21;307(5708):430-3
J:247857 Chornoguz O, et al., mTORC1 Promotes T-bet Phosphorylation To Regulate Th1 Differentiation. J Immunol. 2017 May 15;198(10):3939-3948
J:248943 Levine AG, et al., Stability and function of regulatory T cells expressing the transcription factor T-bet. Nature. 2017 Jun 15;546(7658):421-425
J:259235 Iwata S, et al., The Transcription Factor T-bet Limits Amplification of Type I IFN Transcriptome and Circuitry in T Helper 1 Cells. Immunity. 2017 Jun 20;46(6):983-991.e4