Sequence Detail

ID/Version

Q9JKB1 Q9EQX7 (UniProt | EBI)

Last sequence update: 2001-09-26
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Ubiquitin carboxyl-terminal hydrolase isozyme L3; Short=UCH-L3; EC=3.4.19.12 {ECO:0000250|UniProtKB:P15374};AltName: Full=Ubiquitin thioesterase L3;

Provider

SWISS-PROT

Sequence

Polypeptide 230 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Uchl3	ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)	29	101	3	37

Sequence references in MGI

J:61093 Kurihara LJ, et al., Expression and functional analysis of Uch-L3 during mouse development. Mol Cell Biol. 2000 Apr;20(7):2498-504
J:69453 Osawa Y, et al., Cloning, expression, and mapping of a mouse gene, Uchl4, highly homologous to human and mouse Uchl3. Biochem Biophys Res Commun. 2001 May 11;283(3):627-33
J:110169 Sano Y, et al., Photoreceptor cell apoptosis in the retinal degeneration of uchl3-deficient mice. Am J Pathol. 2006 Jul;169(1):132-41
J:128933 Butterworth MB, et al., The Deubiquitinating Enzyme UCH-L3 Regulates the Apical Membrane Recycling of the Epithelial Sodium Channel. J Biol Chem. 2007 Dec 28;282(52):37885-93
J:158204 Suzuki M, et al., Ubiquitin carboxyl-terminal hydrolase l3 promotes insulin signaling and adipogenesis. Endocrinology. 2009 Dec;150(12):5230-9
J:175529 Dennissen FJ, et al., Mutant ubiquitin (UBB+1) associated with neurodegenerative disorders is hydrolyzed by ubiquitin C-terminal hydrolase L3 (UCH-L3). FEBS Lett. 2011 Aug 19;585(16):2568-74
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:310383 Wood MA, et al., Ubiquitin C-terminal hydrolase L3 (Uchl3) is involved in working memory. Hippocampus. 2005;15(5):610-21