Sequence Detail

ID/Version

Q9JK42 Q8VC63 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial; EC=2.7.11.2 {ECO:0000269|PubMed:22360721};AltName: Full=Pyruvate dehydrogenase kinase isoform 2; Short=PDH kinase 2;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 407 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Pdk2	pyruvate dehydrogenase kinase, isoenzyme 2	20	102	4	9

Sequence references in MGI

J:166353 Degenhardt T, et al., Three members of the human pyruvate dehydrogenase kinase gene family are direct targets of the peroxisome proliferator-activated receptor beta/delta. J Mol Biol. 2007 Sep 14;372(2):341-55
J:168464 Ushikai M, et al., Induction of PDK4 in the heart muscle of JVS mice, an animal model of systemic carnitine deficiency, does not appear to reduce glucose utilization by the heart. Mol Genet Metab. 2011 Mar;102(3):349-55
J:172411 Dunford EC, et al., PDH activation during in vitro muscle contractions in PDH kinase 2 knockout mice: effect of PDH kinase 1 compensation. Am J Physiol Regul Integr Comp Physiol. 2011 Jun;300(6):R1487-93
J:185475 Jeoung NH, et al., Fasting induces ketoacidosis and hypothermia in PDHK2/PDHK4-double-knockout mice. Biochem J. 2012 May 1;443(3):829-39
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89