Sequence Detail

ID/Version

Q9JJF9 Q8R354 A2AI51 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Signal peptide peptidase-like 2A {ECO:0000250|UniProtKB:Q8TCT8}; Short=SPP-like 2A {ECO:0000250|UniProtKB:Q8TCT8}; Short=SPPL2a {ECO:0000250|UniProtKB:Q8TCT8}; EC=3.4.23.-;AltName: Full=Intramembrane protease 3 {ECO:0

Provider

SWISS-PROT

Sequence

Polypeptide 523 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Sppl2a	signal peptide peptidase like 2A	58	98	2	20

Sequence references in MGI

J:176424 Behnke J, et al., Signal-peptide-peptidase-like 2a (SPPL2a) is targeted to lysosomes/late endosomes by a tyrosine motif in its C-terminal tail. FEBS Lett. 2011 Oct 3;585(19):2951-7
J:282524 Kong XF, et al., Disruption of an antimycobacterial circuit between dendritic and helper T cells in human SPPL2a deficiency. Nat Immunol. 2018 Sep;19(9):973-985
J:307733 Gradtke AC, et al., Deficiency of the Intramembrane Protease SPPL2a Alters Antimycobacterial Cytokine Responses of Dendritic Cells. J Immunol. 2021 Jan 1;206(1):164-180