Sequence Detail

ID/Version

Q9JIY2 Q8VCL9 Q3TMC0 Q8C7W5 (UniProt | EBI)

Last sequence update: 2000-10-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=E3 ubiquitin-protein ligase Hakai {ECO:0000305}; EC=2.3.2.27 {ECO:0000269|PubMed:11836526};AltName: Full=Casitas B-lineage lymphoma-transforming sequence-like protein 1 {ECO:0000303|PubMed:11836526}; Short=c-Cbl-like protein

Provider

SWISS-PROT

Sequence

Polypeptide 491 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Cbll1	Casitas B-lineage lymphoma-like 1	37	97	4	10

Sequence references in MGI

J:83415 Fujita Y, et al., Hakai, a c-Cbl-like protein, ubiquitinates and induces endocytosis of the E-cadherin complex. Nat Cell Biol. 2002 Mar;4(3):222-31
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:200486 Mukherjee M, et al., Structure of a novel phosphotyrosine-binding domain in Hakai that targets E-cadherin. EMBO J. 2012 Mar 7;31(5):1308-19
J:261823 Wen J, et al., Zc3h13 Regulates Nuclear RNA m(6)A Methylation and Mouse Embryonic Stem Cell Self-Renewal. Mol Cell. 2018 Mar 15;69(6):1028-1038.e6
J:345540 Knuckles P, et al., Zc3h13/Flacc is required for adenosine methylation by bridging the mRNA-binding factor Rbm15/Spenito to the m(6)A machinery component Wtap/Fl(2)d. Genes Dev. 2018 Mar 1;32(5-6):415-429